Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121446334> ?p ?o ?g. }
- W2121446334 abstract "Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. There are three distinct subtypes of ionotropic glutamate receptors that have been identified including 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptors (AMPARs), N-methyl-D-aspartate receptors (NMDARs) and kainate receptors. The most common glutamate receptors in mature synapses are AMPARs that mediate the fast excitatory neurotransmission and NMDARs that mediate the slow excitatory neurotransmission. There have been large numbers of recent reports studying how a single neuron regulates synaptic numbers and types of AMPARs and NMDARs. Our current research is centered primarily on NMDARs and, therefore, we will focus in this review on recent knowledge of molecular mechanisms occurring 1) early in the biosynthetic pathway of NMDARs, 2) in the transport of NMDARs after their release from the endoplasmic reticulum, and 3) at the plasma membrane including excitatory synapses. Because a growing body of evidence also indicates that abnormalities in NMDAR functioning are associated with a number of human psychiatric and neurological diseases, this review together with other chapters in this issue may help to enhance research and to gain further knowledge of normal synaptic physiology as well as of the etiology of many human brain diseases." @default.
- W2121446334 created "2016-06-24" @default.
- W2121446334 creator A5014911652 @default.
- W2121446334 creator A5041982872 @default.
- W2121446334 creator A5075474558 @default.
- W2121446334 creator A5078385509 @default.
- W2121446334 date "2014-11-27" @default.
- W2121446334 modified "2023-09-27" @default.
- W2121446334 title "ER to synapse trafficking of NMDA receptors" @default.
- W2121446334 cites W1492233936 @default.
- W2121446334 cites W1502426712 @default.
- W2121446334 cites W150356881 @default.
- W2121446334 cites W1511174464 @default.
- W2121446334 cites W1513974586 @default.
- W2121446334 cites W1527134354 @default.
- W2121446334 cites W1530818677 @default.
- W2121446334 cites W1558113371 @default.
- W2121446334 cites W1558650798 @default.
- W2121446334 cites W1577190501 @default.
- W2121446334 cites W1616958874 @default.
- W2121446334 cites W1648575050 @default.
- W2121446334 cites W1653383134 @default.
- W2121446334 cites W1765307519 @default.
- W2121446334 cites W1915631305 @default.
- W2121446334 cites W1918304474 @default.
- W2121446334 cites W1960769979 @default.
- W2121446334 cites W1965191426 @default.
- W2121446334 cites W1965522502 @default.
- W2121446334 cites W1965571756 @default.
- W2121446334 cites W1966556202 @default.
- W2121446334 cites W1967020613 @default.
- W2121446334 cites W1967077233 @default.
- W2121446334 cites W1972292788 @default.
- W2121446334 cites W1972462790 @default.
- W2121446334 cites W1973573917 @default.
- W2121446334 cites W1974482933 @default.
- W2121446334 cites W1974587074 @default.
- W2121446334 cites W1974838199 @default.
- W2121446334 cites W1977048478 @default.
- W2121446334 cites W1977394169 @default.
- W2121446334 cites W1978044509 @default.
- W2121446334 cites W1978458868 @default.
- W2121446334 cites W1980059018 @default.
- W2121446334 cites W1980311878 @default.
- W2121446334 cites W1980971000 @default.
- W2121446334 cites W1982275335 @default.
- W2121446334 cites W1983102912 @default.
- W2121446334 cites W1983419147 @default.
- W2121446334 cites W1984402158 @default.
- W2121446334 cites W1984538804 @default.
- W2121446334 cites W1986435945 @default.
- W2121446334 cites W1988594478 @default.
- W2121446334 cites W1991437616 @default.
- W2121446334 cites W1991587039 @default.
- W2121446334 cites W1991822191 @default.
- W2121446334 cites W1992307803 @default.
- W2121446334 cites W1997078443 @default.
- W2121446334 cites W1997081065 @default.
- W2121446334 cites W1997167669 @default.
- W2121446334 cites W1998688864 @default.
- W2121446334 cites W1998895310 @default.
- W2121446334 cites W1999127875 @default.
- W2121446334 cites W1999744152 @default.
- W2121446334 cites W2001248033 @default.
- W2121446334 cites W2002287054 @default.
- W2121446334 cites W2003443990 @default.
- W2121446334 cites W2003701228 @default.
- W2121446334 cites W2003875374 @default.
- W2121446334 cites W2004427197 @default.
- W2121446334 cites W2005099102 @default.
- W2121446334 cites W2005770471 @default.
- W2121446334 cites W2007018052 @default.
- W2121446334 cites W2007114792 @default.
- W2121446334 cites W2007387168 @default.
- W2121446334 cites W2008763819 @default.
- W2121446334 cites W2009359439 @default.
- W2121446334 cites W2009847863 @default.
- W2121446334 cites W2010152646 @default.
- W2121446334 cites W2011280723 @default.
- W2121446334 cites W2011875417 @default.
- W2121446334 cites W2012825486 @default.
- W2121446334 cites W2015951549 @default.
- W2121446334 cites W2016366195 @default.
- W2121446334 cites W2016542252 @default.
- W2121446334 cites W2019009655 @default.
- W2121446334 cites W2024380057 @default.
- W2121446334 cites W2025722885 @default.
- W2121446334 cites W2026429446 @default.
- W2121446334 cites W2026800766 @default.
- W2121446334 cites W2029534471 @default.
- W2121446334 cites W2030284957 @default.
- W2121446334 cites W2030322110 @default.
- W2121446334 cites W2030868502 @default.
- W2121446334 cites W2032560275 @default.
- W2121446334 cites W2034272820 @default.
- W2121446334 cites W2034297330 @default.
- W2121446334 cites W2034762571 @default.
- W2121446334 cites W2036658681 @default.
- W2121446334 cites W2036796078 @default.
- W2121446334 cites W2037038958 @default.