Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121454432> ?p ?o ?g. }
- W2121454432 endingPage "2551" @default.
- W2121454432 startingPage "2537" @default.
- W2121454432 abstract "The ubiquitin-proteasome pathway (UPP), which influences essential cellular functions including cell growth, differentiation, apoptosis, signal transduction, antigen processing and inflammatory responses, has been considered as one of the most important cellular protein degradation approaches. Proteasome functions as a gatekeeper, which controls the execution of protein degradation and plays a critical role in the ubiquitin-proteasome pathway. The unfolding of the close connection between proteasome and cancer provides a potential strategy for cancer treatment by using proteasome inhibitors. Small molecular inhibitors of varied structures and potency against proteasome have been discovered in recent years, with bortezomib and carfilzomib having been successfully approved for clinical application while some other promising candidates are currently under clinical trials. Herein, we review the development history of drugs and candidates that target the 20S proteasome, structure-activity relationships (SARs) of various proteasome inhibitors, and related completed or ongoing clinical trials. Keywords: Cancer, clinical development, marketed, proteasome, proteasome inhibitor, SAR." @default.
- W2121454432 created "2016-06-24" @default.
- W2121454432 creator A5000589535 @default.
- W2121454432 creator A5004572890 @default.
- W2121454432 creator A5067509102 @default.
- W2121454432 date "2013-05-01" @default.
- W2121454432 modified "2023-09-25" @default.
- W2121454432 title "Clinical and Marketed Proteasome Inhibitors for Cancer Treatment" @default.
- W2121454432 cites W1518129172 @default.
- W2121454432 cites W1518640128 @default.
- W2121454432 cites W1571433223 @default.
- W2121454432 cites W1603251764 @default.
- W2121454432 cites W170914365 @default.
- W2121454432 cites W1838166837 @default.
- W2121454432 cites W1911489485 @default.
- W2121454432 cites W1964602059 @default.
- W2121454432 cites W1966544200 @default.
- W2121454432 cites W1966704794 @default.
- W2121454432 cites W1973963032 @default.
- W2121454432 cites W1975305152 @default.
- W2121454432 cites W1975378756 @default.
- W2121454432 cites W1975462016 @default.
- W2121454432 cites W1976449876 @default.
- W2121454432 cites W1986329393 @default.
- W2121454432 cites W1987583882 @default.
- W2121454432 cites W1988775004 @default.
- W2121454432 cites W1988859277 @default.
- W2121454432 cites W1989118295 @default.
- W2121454432 cites W1991101546 @default.
- W2121454432 cites W1992978957 @default.
- W2121454432 cites W1994866501 @default.
- W2121454432 cites W1995596496 @default.
- W2121454432 cites W1995805772 @default.
- W2121454432 cites W1996091402 @default.
- W2121454432 cites W1999119754 @default.
- W2121454432 cites W2002349799 @default.
- W2121454432 cites W2004782513 @default.
- W2121454432 cites W2007456673 @default.
- W2121454432 cites W2010184965 @default.
- W2121454432 cites W2010228920 @default.
- W2121454432 cites W2011163336 @default.
- W2121454432 cites W2013644117 @default.
- W2121454432 cites W2016098671 @default.
- W2121454432 cites W2016742872 @default.
- W2121454432 cites W2020031294 @default.
- W2121454432 cites W2023486531 @default.
- W2121454432 cites W2025963365 @default.
- W2121454432 cites W2031286256 @default.
- W2121454432 cites W2033394004 @default.
- W2121454432 cites W2033944464 @default.
- W2121454432 cites W2036211695 @default.
- W2121454432 cites W2038043887 @default.
- W2121454432 cites W2038430270 @default.
- W2121454432 cites W2039839254 @default.
- W2121454432 cites W2042710439 @default.
- W2121454432 cites W2043385261 @default.
- W2121454432 cites W2043943641 @default.
- W2121454432 cites W2045015032 @default.
- W2121454432 cites W2056402897 @default.
- W2121454432 cites W2059515537 @default.
- W2121454432 cites W2060736209 @default.
- W2121454432 cites W2061194648 @default.
- W2121454432 cites W2066284211 @default.
- W2121454432 cites W2067653691 @default.
- W2121454432 cites W2069992059 @default.
- W2121454432 cites W2070854644 @default.
- W2121454432 cites W2071191421 @default.
- W2121454432 cites W2075768627 @default.
- W2121454432 cites W2076013759 @default.
- W2121454432 cites W2085092447 @default.
- W2121454432 cites W2085459881 @default.
- W2121454432 cites W2089865526 @default.
- W2121454432 cites W2091020556 @default.
- W2121454432 cites W2091378741 @default.
- W2121454432 cites W2091403769 @default.
- W2121454432 cites W2092126330 @default.
- W2121454432 cites W2094471234 @default.
- W2121454432 cites W2096558029 @default.
- W2121454432 cites W2099117007 @default.
- W2121454432 cites W2101759139 @default.
- W2121454432 cites W2106379961 @default.
- W2121454432 cites W2107529999 @default.
- W2121454432 cites W2109371953 @default.
- W2121454432 cites W2111129974 @default.
- W2121454432 cites W2122515314 @default.
- W2121454432 cites W2122684890 @default.
- W2121454432 cites W2123322767 @default.
- W2121454432 cites W2124560610 @default.
- W2121454432 cites W2126235934 @default.
- W2121454432 cites W2126267349 @default.
- W2121454432 cites W2127760782 @default.
- W2121454432 cites W2134306287 @default.
- W2121454432 cites W2134366646 @default.
- W2121454432 cites W2138432086 @default.
- W2121454432 cites W2140113033 @default.
- W2121454432 cites W2143589401 @default.
- W2121454432 cites W2145887093 @default.
- W2121454432 cites W2145932487 @default.