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• W2121460992 abstract "Au cute viral myocarditis is a disease caused by vis multiplication in the myocardium leading to mononuclear cellular infiltration. The heart is infiltrated first by natural killer cells which express a cytolytic factor and then by activated T-cells. The inflammatory reaction, and possibly an autoimmune response, leads to multiple foci of necrosis followed by fibrosis. The clinical picture ranges from very mild, often unrecognized illness, to severe cardiac involvement, presenting as end-stage heart failure. Following its recognition in the early 1 BOOS, treatment included the use of mercurial diuretics, digitalis, large doses of vitamins, and a variety of antisera and antitoxins.’ None of these therapeutic modalities had any impact on the disease process, and for well over a century, the only recommendation was for prolonged bed rest as suggested by Reid.* It was not until the introduction of the animal models of viral myocarditis that a true impact on therapy was achieved. 3*4 The murine model of viral myocarditis probably has had the most impact on therapy. In this model, 2to 3-week-old mice are injected intraperitoneally with the virus. Several viruses have been utilized, but coxsackievirus and encephalomyocarditis virus are the most common. Coxsackievirus infects both man and mice, and its course in both species is virtually the same. Encephalomyocarditis virus infects primarily rodents and is characterized by early development of dilated cardiomyopathy. The virus starts to multiply and within days viral myocarditis is usually established in mice. The disease process in mice parallels that of human myocarditis, and essentially goes through 2 phases. The acute phase is the phase of viral replication where the virus can be isolated from blood and heart. Heart sections will also show cellular infiltration, cardiac necrosis, and dystrophic calcifications. The chronic phase is the phase of developing progressive heart failure and is characterized by foci of fibrosis. The degree of severity of disease correlates with the amount of virus injected. This editorial will review various therapeutic modalities that were studied in acute viral myocarditis with emphasis on laboratory investigations and the potential role of captopiil." @default.
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• W2121460992 title "Treatment of viral myocarditis with focus on captopril" @default.
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• W2121460992 doi "https://doi.org/10.1016/s0002-9149(97)89320-4" @default.
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