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• W2121467462 endingPage "52" @default.
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• W2121467462 abstract "Thymic development proceeds in stages whereby immature T-cell precursors lacking T-cell receptor (TCR) and CD4 and CD8 expression (double negative: DN), progress through a TCRlo CD4+CD8+ (double positive: DP) stage before differentiating into mature TCRhi CD4+CD8− or CD4−CD8+ (single positive: SP) thymocytes.1 DP thymocytes are subjected to positive and negative selection.2 Positive selection results in the development of a peripheral T-cell population capable of responding to antigen presented in the context of self major histocompatibility complex (MHC). Negative selection eliminates T cells with potentially harmful self-reactivity. This process is defined as clonal deletion. DP thymocytes which are not clonally deleted progress to a mature SP stage." @default.
• W2121467462 created "2016-06-24" @default.
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• W2121467462 date "1995-01-01" @default.
• W2121467462 modified "2023-10-17" @default.
• W2121467462 title "Human T-Cell Development in SCID-hu Mice" @default.
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• W2121467462 doi "https://doi.org/10.1007/978-3-662-22008-5_3" @default.
• W2121467462 hasPublicationYear "1995" @default.
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