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• W2121481695 abstract "Purified phage lysins present an alternative to traditional antibiotics and work by hydrolysing peptidoglycan. Phage lysins have been developed against Gram-positive pathogens such as Bacillus anthracis and Streptococcus pneumoniae, where the peptidoglycan layer is exposed on the cell surface. Addition of the lysin to a bacterial culture results in rapid death of the organism. Gram-negative bacteria are resistant to phage lysins because they contain an outer membrane that protects the peptidoglycan from degradation. We solved crystal structures of a Yersinia pestis outer-membrane protein and the bacteriocin that targets it, which informed engineering of a bacterial–phage hybrid lysin that can be transported across the outer membrane to kill specific Gram-negative bacteria. This work provides a template for engineering phage lysins against a wide variety of bacterial pathogens." @default.
• W2121481695 created "2016-06-24" @default.
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• W2121481695 date "2012-11-21" @default.
• W2121481695 modified "2023-09-29" @default.
• W2121481695 title "Using a bacteriocin structure to engineer a phage lysin that targets <i>Yersinia pestis</i>" @default.
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• W2121481695 doi "https://doi.org/10.1042/bst20120209" @default.
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