Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121498145> ?p ?o ?g. }
- W2121498145 endingPage "53" @default.
- W2121498145 startingPage "29" @default.
- W2121498145 abstract "T cell activation is dependent upon signals delivered through the antigen-specific T cell receptor and accessory receptors on the T cell. A primary costimulatory signal is delivered through the CD28 receptor after engagement of its ligands, B7-1 (CD80) or B7-2 (CD86). Engagement of CTLA-4 (CD152) by the same B7-1 or B7-2 ligands results in attenuation of T cells responses. Recently, molecular homologs of CD28 and CTLA-4 receptors and their B7-like ligands have been identified. ICOS is a CD28-like costimulatory receptor with a unique B7-like ligand. PD-1 is an inhibitory receptor, with two B7-like ligands. Additional members of B7 and CD28 gene families have been proposed. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands is critical for activation of immune responses and tolerance. Understanding these pathways will allow development of new strategies for therapeutic intervention in immune-mediated diseases." @default.
- W2121498145 created "2016-06-24" @default.
- W2121498145 creator A5000653097 @default.
- W2121498145 creator A5006809226 @default.
- W2121498145 date "2002-04-01" @default.
- W2121498145 modified "2023-10-04" @default.
- W2121498145 title "The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses" @default.
- W2121498145 cites W118130514 @default.
- W2121498145 cites W1498638197 @default.
- W2121498145 cites W1538902372 @default.
- W2121498145 cites W1542262758 @default.
- W2121498145 cites W1548331405 @default.
- W2121498145 cites W1564765245 @default.
- W2121498145 cites W1568317937 @default.
- W2121498145 cites W1581138690 @default.
- W2121498145 cites W1604334489 @default.
- W2121498145 cites W1613769575 @default.
- W2121498145 cites W1626388077 @default.
- W2121498145 cites W1639242915 @default.
- W2121498145 cites W1661441964 @default.
- W2121498145 cites W1667545291 @default.
- W2121498145 cites W1898621392 @default.
- W2121498145 cites W1926858130 @default.
- W2121498145 cites W1951252517 @default.
- W2121498145 cites W1953398467 @default.
- W2121498145 cites W1966930760 @default.
- W2121498145 cites W1968546256 @default.
- W2121498145 cites W1969466880 @default.
- W2121498145 cites W1970703215 @default.
- W2121498145 cites W1973006183 @default.
- W2121498145 cites W1976930581 @default.
- W2121498145 cites W1987058098 @default.
- W2121498145 cites W1993219448 @default.
- W2121498145 cites W1995254015 @default.
- W2121498145 cites W2001287101 @default.
- W2121498145 cites W2010660594 @default.
- W2121498145 cites W2013465459 @default.
- W2121498145 cites W2013624346 @default.
- W2121498145 cites W2015085911 @default.
- W2121498145 cites W2026893575 @default.
- W2121498145 cites W2038313541 @default.
- W2121498145 cites W2040164466 @default.
- W2121498145 cites W2041980736 @default.
- W2121498145 cites W2043397806 @default.
- W2121498145 cites W2045313390 @default.
- W2121498145 cites W2045932062 @default.
- W2121498145 cites W2047475159 @default.
- W2121498145 cites W2051304739 @default.
- W2121498145 cites W2051307768 @default.
- W2121498145 cites W2052077392 @default.
- W2121498145 cites W2054083392 @default.
- W2121498145 cites W2056535502 @default.
- W2121498145 cites W2058649993 @default.
- W2121498145 cites W2061252374 @default.
- W2121498145 cites W2069080743 @default.
- W2121498145 cites W2069377196 @default.
- W2121498145 cites W2070668733 @default.
- W2121498145 cites W2073620498 @default.
- W2121498145 cites W2076067786 @default.
- W2121498145 cites W2082871926 @default.
- W2121498145 cites W2082878575 @default.
- W2121498145 cites W2090481553 @default.
- W2121498145 cites W2091783976 @default.
- W2121498145 cites W2093542451 @default.
- W2121498145 cites W2094991897 @default.
- W2121498145 cites W2098658552 @default.
- W2121498145 cites W2098853737 @default.
- W2121498145 cites W2100304857 @default.
- W2121498145 cites W2101990345 @default.
- W2121498145 cites W2102435149 @default.
- W2121498145 cites W2105372977 @default.
- W2121498145 cites W2107752337 @default.
- W2121498145 cites W2114866206 @default.
- W2121498145 cites W2116169737 @default.
- W2121498145 cites W2118175246 @default.
- W2121498145 cites W2118471749 @default.
- W2121498145 cites W2121934915 @default.
- W2121498145 cites W2124060252 @default.
- W2121498145 cites W2125582444 @default.
- W2121498145 cites W2127387126 @default.
- W2121498145 cites W2128810183 @default.
- W2121498145 cites W2133866843 @default.
- W2121498145 cites W2136866940 @default.
- W2121498145 cites W2140173643 @default.
- W2121498145 cites W2145871366 @default.
- W2121498145 cites W2146361966 @default.
- W2121498145 cites W2150024706 @default.
- W2121498145 cites W2150396211 @default.
- W2121498145 cites W2151962109 @default.
- W2121498145 cites W2157787652 @default.
- W2121498145 cites W2162380170 @default.
- W2121498145 cites W2162466652 @default.
- W2121498145 cites W2164570854 @default.
- W2121498145 cites W2164903177 @default.
- W2121498145 cites W2171026458 @default.
- W2121498145 cites W2182386412 @default.
- W2121498145 cites W2614575602 @default.
- W2121498145 cites W4320800157 @default.