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• W2121520274 abstract "The ras genes of BALB and Harvey sarcoma viruses contain point mutations in codon 12 or codons 12 and 59, relative to proto-ras from normal animal and human cells. By in vitro recombination between cloned rat proto-ras and cloned BALB and Harvey sarcoma proviruses, we constructed recombinant proviruses with normal proto-ras-coding regions. These recombinant proviruses transformed mouse 3T3 cells upon transfection. However, when the transforming efficiencies of proviral DNAs were compared after transfection with helper provirus, recombinant proviruses were 2 to 30 times less efficient than the corresponding wild-type proviruses. Recombinant sarcoma viruses isolated from cells transformed by cloned proviral DNA contained the expected normal ras-coding region. They transformed rat embryo cells and induced erythroblastosis and sarcomas in newborn mice as efficiently as wild-type viruses did. We conclude that conversion of normal proto-ras genes to viral ras genes depends on truncation of normal proto-ras regulatory elements and substitution by retroviral (long terminal repeat) promoters and that the transforming function of long terminal repeat-ras genes is enhanced by point mutations." @default.
• W2121520274 created "2016-06-24" @default.
• W2121520274 creator A5010111166 @default.
• W2121520274 creator A5036211072 @default.
• W2121520274 date "1989-03-01" @default.
• W2121520274 modified "2023-10-15" @default.
• W2121520274 title "Recombinant BALB and Harvey sarcoma viruses with normal proto-ras-coding regions transform embryo cells in culture and cause tumors in mice" @default.
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• W2121520274 doi "https://doi.org/10.1128/jvi.63.3.1377-1383.1989" @default.
• W2121520274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/247836" @default.
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