FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121541569> ?p ?o ?g. }

• W2121541569 endingPage "L1272" @default.
• W2121541569 startingPage "L1263" @default.
• W2121541569 abstract "The human airway trypsin-like protease (HAT) is a respiratory epithelium-associated, type II transmembrane serine protease, which is also detected as an extracellular enzyme in lung fluids during airway inflammatory disorders. We have evaluated its capacity to affect the urokinase-type plasminogen activator receptor (uPAR), a membrane glycolipid-anchored, three-domain (D1D2D3) glycoprotein that plays a crucial role in innate immunity and inflammation by supporting cell migration and matrix degradation, with structure and biological properties that can be regulated via limited endoproteolysis. With the use of immunoblotting, flow immunocytometry, and ELISA analyses applied to a recombinant uPAR protein and to uPAR-expressing monocytic and human bronchial epithelial cells, it was shown that exposure of uPAR to soluble HAT in the range of 10-500 nM resulted in the proteolytic processing of the full-length (D1D2D3) into the truncated (D2D3) species, with cleavage occurring in the D1 to D2 linker sequence after arginine residues at position 83 and 89. Using immunohistochemistry, we found that both HAT and uPAR were expressed in the human bronchial epithelium. Moreover, transient cotransfection in epithelial cells showed that membrane coexpression of the two partners produced a constitutive and extensive shedding of the D1 domain, occurring for membrane-associated HAT concentrations in the nanomolar range. Because the truncated receptor was found to be unable to bind two of the major uPAR ligands, the adhesive matrix protein vitronectin and the serine protease urokinase, it thus appears that proteolytic regulation of uPAR by HAT is likely to modulate cell adherence and motility, as well as tissue remodeling during the inflammatory response in the airways." @default.
• W2121541569 created "2016-06-24" @default.
• W2121541569 creator A5003549351 @default.
• W2121541569 creator A5021509194 @default.
• W2121541569 creator A5022752354 @default.
• W2121541569 creator A5030552991 @default.
• W2121541569 creator A5045555453 @default.
• W2121541569 creator A5058803641 @default.
• W2121541569 creator A5065746564 @default.
• W2121541569 creator A5066686177 @default.
• W2121541569 creator A5069512682 @default.
• W2121541569 creator A5082347184 @default.
• W2121541569 creator A5089047086 @default.
• W2121541569 date "2007-05-01" @default.
• W2121541569 modified "2023-09-30" @default.
• W2121541569 title "The human airway trypsin-like protease modulates the urokinase receptor (uPAR, CD87) structure and functions" @default.
• W2121541569 cites W1481224849 @default.
• W2121541569 cites W1514221498 @default.
• W2121541569 cites W1670322156 @default.
• W2121541569 cites W1967205709 @default.
• W2121541569 cites W1970432654 @default.
• W2121541569 cites W1974471520 @default.
• W2121541569 cites W1977765902 @default.
• W2121541569 cites W1986658649 @default.
• W2121541569 cites W2005644246 @default.
• W2121541569 cites W2010695917 @default.
• W2121541569 cites W2012408120 @default.
• W2121541569 cites W2027837178 @default.
• W2121541569 cites W2036952631 @default.
• W2121541569 cites W2049440078 @default.
• W2121541569 cites W2050866138 @default.
• W2121541569 cites W2056501914 @default.
• W2121541569 cites W2056516635 @default.
• W2121541569 cites W2059590594 @default.
• W2121541569 cites W2070975187 @default.
• W2121541569 cites W2077006158 @default.
• W2121541569 cites W2080021145 @default.
• W2121541569 cites W2092565468 @default.
• W2121541569 cites W2092839736 @default.
• W2121541569 cites W2097416760 @default.
• W2121541569 cites W2102910454 @default.
• W2121541569 cites W2112978304 @default.
• W2121541569 cites W2116938697 @default.
• W2121541569 cites W2124200027 @default.
• W2121541569 cites W2133764756 @default.
• W2121541569 cites W2140380036 @default.
• W2121541569 cites W2146983151 @default.
• W2121541569 cites W2153784945 @default.
• W2121541569 cites W2159269876 @default.
• W2121541569 cites W2413224675 @default.
• W2121541569 cites W341360274 @default.
• W2121541569 cites W4245713972 @default.
• W2121541569 doi "https://doi.org/10.1152/ajplung.00191.2006" @default.
• W2121541569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17237151" @default.
• W2121541569 hasPublicationYear "2007" @default.
• W2121541569 type Work @default.
• W2121541569 sameAs 2121541569 @default.
• W2121541569 citedByCount "39" @default.
• W2121541569 countsByYear W21215415692012 @default.
• W2121541569 countsByYear W21215415692013 @default.
• W2121541569 countsByYear W21215415692014 @default.
• W2121541569 countsByYear W21215415692016 @default.
• W2121541569 countsByYear W21215415692017 @default.
• W2121541569 countsByYear W21215415692018 @default.
• W2121541569 countsByYear W21215415692019 @default.
• W2121541569 countsByYear W21215415692021 @default.
• W2121541569 countsByYear W21215415692022 @default.
• W2121541569 countsByYear W21215415692023 @default.
• W2121541569 crossrefType "journal-article" @default.
• W2121541569 hasAuthorship W2121541569A5003549351 @default.
• W2121541569 hasAuthorship W2121541569A5021509194 @default.
• W2121541569 hasAuthorship W2121541569A5022752354 @default.
• W2121541569 hasAuthorship W2121541569A5030552991 @default.
• W2121541569 hasAuthorship W2121541569A5045555453 @default.
• W2121541569 hasAuthorship W2121541569A5058803641 @default.
• W2121541569 hasAuthorship W2121541569A5065746564 @default.
• W2121541569 hasAuthorship W2121541569A5066686177 @default.
• W2121541569 hasAuthorship W2121541569A5069512682 @default.
• W2121541569 hasAuthorship W2121541569A5082347184 @default.
• W2121541569 hasAuthorship W2121541569A5089047086 @default.
• W2121541569 hasConcept C104317684 @default.
• W2121541569 hasConcept C125268873 @default.
• W2121541569 hasConcept C134018914 @default.
• W2121541569 hasConcept C153911025 @default.
• W2121541569 hasConcept C164144092 @default.
• W2121541569 hasConcept C170493617 @default.
• W2121541569 hasConcept C181199279 @default.
• W2121541569 hasConcept C182220744 @default.
• W2121541569 hasConcept C185592680 @default.
• W2121541569 hasConcept C195687474 @default.
• W2121541569 hasConcept C2776714187 @default.
• W2121541569 hasConcept C2776892390 @default.
• W2121541569 hasConcept C2777807008 @default.
• W2121541569 hasConcept C2779679481 @default.
• W2121541569 hasConcept C2781071845 @default.
• W2121541569 hasConcept C54009773 @default.
• W2121541569 hasConcept C54355233 @default.
• W2121541569 hasConcept C55493867 @default.

• next