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• W2121542235 endingPage "1358" @default.
• W2121542235 startingPage "1352" @default.
• W2121542235 abstract "Activin A regulation of the expression of mRNA for the LH receptor, FSH receptor, and the inhibin α subunit as well as the effect of activin A on the secretion of progesterone were investigated in chicken granulosa cell cultures. Granulosa layers were isolated from the F1 and F3 + F4 follicles from five hens, pooled according to size, dispersed, and cultured for 48 h. In experiment 1 (n = 3 replications), granulosa cells were cultured with or without highly purified ovine (o) FSH at 50 ng/ml and in the presence of 0, 10, or 50 ng/ml of recombinant chicken activin A. Experiment 2 (n = 4 replications) followed the same protocol as experiment 1, except that oFSH was replaced with oLH. Results from these experiments showed that addition of activin A to the granulosa cell cultures had no effect on the expression of mRNA for the inhibin α subunit or the FSH receptor, but it did affect the expression of mRNA for the LH receptor. Treatment of F3 + F4 granulosa cells with LH stimulated the expression of mRNA for the LH receptor; however, when LH was combined with either dose of activin A, this induction was prevented. The highest dose of activin A with or without LH resulted in decreased expression of the LH receptor compared to the untreated controls in the F3 + F4 cell cultures. Progesterone secretion by the granulosa cells from both follicle sizes was not altered by activin A. In experiment 3 (n = 3 replications), the effect of activin A on the growth of granulosa cells was examined with the following treatments: 0, 10, or 50 ng/ml of activin A; 50 ng/ml of either oLH or oFSH; and oLH or oFSH combined with 10 ng/ml of activin A. The highest dose of activin reduced the rate of granulosa cell proliferation in both follicle types. Growth of F1 and F3 + F4 granulosa cells was stimulated by the addition of either gonadotropin, and the presence of 10 ng/ml of activin A with either gonadotropin did not alter this proliferation, except for the LH-treated F3 + F4 granulosa cells, in which the increase in proliferation was prevented. The results suggest that activin A could act as a local factor that regulates follicular maturation by preventing excessive or untimely LH receptor expression." @default.
• W2121542235 created "2016-06-24" @default.
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• W2121542235 creator A5035359387 @default.
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• W2121542235 date "2001-11-01" @default.
• W2121542235 modified "2023-10-01" @default.
• W2121542235 title "Activin A and Gonadotropin Regulation of Follicle-Stimulating Hormone and Luteinizing Hormone Receptor Messenger RNA in Avian Granulosa Cells1" @default.
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• W2121542235 doi "https://doi.org/10.1095/biolreprod65.5.1352" @default.
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