FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121550713> ?p ?o ?g. }

• W2121550713 endingPage "527" @default.
• W2121550713 startingPage "518" @default.
• W2121550713 abstract "T-cell prolymphocytic leukemia is a rare aggressive lymphoproliferative disease with a mature T-cell phenotype and characteristic genomic lesions such as inv(14)(q11q34), t(14;14)(q11;q32) or t(X;14)(q28;q11), mutation of the ATM gene on chromosome 11 and secondary alterations such as deletions of chromosome 8p and duplications of 8q.We analyzed malignant cells from 18 patients with T-cell prolymphocytic leukemia using high density 250K single nucleotide polymorphism arrays and molecular allelokaryotyping to refine understanding of known alterations and identify new target genes.Our analyses revealed that characteristic disruptions of chromosome 14 are frequently unbalanced. In the commonly deleted region on chromosome 11, we found recurrent microdeletions targeting the microRNA 34b/c and the transcription factors ETS1 and FLI1. On chromosome 8, we identified genes such as PLEKHA2, NBS1, NOV and MYST3 to be involved in breakpoints. New recurrent alterations were identified on chromosomes 5p, 12p, 13q, 17 and 22 with a common region of acquired uniparental disomy in four samples on chromosome 17q. Single nucleotide polymorphism array results were confirmed by direct sequencing and quantitative real-time polymerase chain reaction.The first high density single nucleotide polymorphism array allelokaryotyping of T-cell prolymphocytic leukemia genomes added substantial new details about established alterations in this disease and moreover identified numerous new potential target genes in common breakpoints, deletions and regions of acquired uniparental disomy." @default.
• W2121550713 created "2016-06-24" @default.
• W2121550713 creator A5029332875 @default.
• W2121550713 creator A5032690457 @default.
• W2121550713 creator A5042588749 @default.
• W2121550713 creator A5047228096 @default.
• W2121550713 creator A5055601574 @default.
• W2121550713 creator A5061189755 @default.
• W2121550713 creator A5064627617 @default.
• W2121550713 creator A5081516283 @default.
• W2121550713 creator A5082903377 @default.
• W2121550713 date "2009-04-01" @default.
• W2121550713 modified "2023-10-12" @default.
• W2121550713 title "Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy" @default.
• W2121550713 cites W173841824 @default.
• W2121550713 cites W1844220054 @default.
• W2121550713 cites W1872489376 @default.
• W2121550713 cites W1977193819 @default.
• W2121550713 cites W1981743953 @default.
• W2121550713 cites W1981896461 @default.
• W2121550713 cites W1982634023 @default.
• W2121550713 cites W1987049613 @default.
• W2121550713 cites W1987264710 @default.
• W2121550713 cites W2000580348 @default.
• W2121550713 cites W2001931464 @default.
• W2121550713 cites W2011548242 @default.
• W2121550713 cites W2021692298 @default.
• W2121550713 cites W2031916348 @default.
• W2121550713 cites W2036640462 @default.
• W2121550713 cites W2036794512 @default.
• W2121550713 cites W2038067635 @default.
• W2121550713 cites W2038167014 @default.
• W2121550713 cites W2042358998 @default.
• W2121550713 cites W2042688319 @default.
• W2121550713 cites W2060761276 @default.
• W2121550713 cites W2064377499 @default.
• W2121550713 cites W2070032322 @default.
• W2121550713 cites W2073449138 @default.
• W2121550713 cites W2083158631 @default.
• W2121550713 cites W2084887131 @default.
• W2121550713 cites W2087239831 @default.
• W2121550713 cites W2093099038 @default.
• W2121550713 cites W2107638327 @default.
• W2121550713 cites W2111655556 @default.
• W2121550713 cites W2119967034 @default.
• W2121550713 cites W2124116341 @default.
• W2121550713 cites W2128660988 @default.
• W2121550713 cites W2131418340 @default.
• W2121550713 cites W2131826493 @default.
• W2121550713 cites W2135284044 @default.
• W2121550713 cites W2135314242 @default.
• W2121550713 cites W2136844938 @default.
• W2121550713 cites W2138275899 @default.
• W2121550713 cites W2143234217 @default.
• W2121550713 cites W2151595196 @default.
• W2121550713 cites W2159778357 @default.
• W2121550713 cites W2168799171 @default.
• W2121550713 cites W2169830490 @default.
• W2121550713 cites W2253277805 @default.
• W2121550713 cites W2326722293 @default.
• W2121550713 cites W2369302706 @default.
• W2121550713 cites W2980160077 @default.
• W2121550713 cites W84003226 @default.
• W2121550713 doi "https://doi.org/10.3324/haematol.2008.001347" @default.
• W2121550713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663615" @default.
• W2121550713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19278963" @default.
• W2121550713 hasPublicationYear "2009" @default.
• W2121550713 type Work @default.
• W2121550713 sameAs 2121550713 @default.
• W2121550713 citedByCount "27" @default.
• W2121550713 countsByYear W21215507132012 @default.
• W2121550713 countsByYear W21215507132014 @default.
• W2121550713 countsByYear W21215507132015 @default.
• W2121550713 countsByYear W21215507132017 @default.
• W2121550713 countsByYear W21215507132020 @default.
• W2121550713 countsByYear W21215507132022 @default.
• W2121550713 crossrefType "journal-article" @default.
• W2121550713 hasAuthorship W2121550713A5029332875 @default.
• W2121550713 hasAuthorship W2121550713A5032690457 @default.
• W2121550713 hasAuthorship W2121550713A5042588749 @default.
• W2121550713 hasAuthorship W2121550713A5047228096 @default.
• W2121550713 hasAuthorship W2121550713A5055601574 @default.
• W2121550713 hasAuthorship W2121550713A5061189755 @default.
• W2121550713 hasAuthorship W2121550713A5064627617 @default.
• W2121550713 hasAuthorship W2121550713A5081516283 @default.
• W2121550713 hasAuthorship W2121550713A5082903377 @default.
• W2121550713 hasBestOaLocation W21215507131 @default.
• W2121550713 hasConcept C104317684 @default.
• W2121550713 hasConcept C120821319 @default.
• W2121550713 hasConcept C124942203 @default.
• W2121550713 hasConcept C135763542 @default.
• W2121550713 hasConcept C141231307 @default.
• W2121550713 hasConcept C153209595 @default.
• W2121550713 hasConcept C153911025 @default.
• W2121550713 hasConcept C2775983024 @default.
• W2121550713 hasConcept C2777938653 @default.
• W2121550713 hasConcept C2778461978 @default.
• W2121550713 hasConcept C2780332060 @default.

• next