Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121554658> ?p ?o ?g. }
- W2121554658 endingPage "e27925" @default.
- W2121554658 startingPage "e27925" @default.
- W2121554658 abstract "This study aims to differentiate human induced pluripotent stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a demyelinated optic chiasm model in rats.We generated a cell population of oligodendrocyte progenitors from hiPSCs by using embryoid body formation in a defined medium supplemented with a combination of factors, positive selection and mechanical enrichment. Real-time polymerase chain reaction and immunofluorescence analyses showed that stage-specific markers, Olig2, Sox10, NG2, PDGFRα, O4, A2B5, GalC, and MBP were expressed following the differentiation procedure, and enrichment of the oligodendrocyte lineage. These results are comparable with the expression of stage-specific markers in human embryonic stem cell-derived oligodendrocyte lineage cells. Transplantation of hiPSC-derived oligodendrocyte progenitors into the lysolecithin-induced demyelinated optic chiasm of the rat model resulted in recovery from symptoms, and integration and differentiation into oligodendrocytes were detected by immunohistofluorescence staining against PLP and MBP, and measurements of the visual evoked potentials.These results showed that oligodendrocyte progenitors generated efficiently from hiPSCs can be used in future biomedical studies once safety issues have been overcome." @default.
- W2121554658 created "2016-06-24" @default.
- W2121554658 creator A5024072918 @default.
- W2121554658 creator A5057349948 @default.
- W2121554658 creator A5069750818 @default.
- W2121554658 creator A5078662901 @default.
- W2121554658 creator A5091186278 @default.
- W2121554658 date "2011-11-18" @default.
- W2121554658 modified "2023-10-16" @default.
- W2121554658 title "Human Induced Pluripotent Stem Cells Differentiation into Oligodendrocyte Progenitors and Transplantation in a Rat Model of Optic Chiasm Demyelination" @default.
- W2121554658 cites W1516649135 @default.
- W2121554658 cites W1889195978 @default.
- W2121554658 cites W1958675029 @default.
- W2121554658 cites W1964224339 @default.
- W2121554658 cites W1965474066 @default.
- W2121554658 cites W1965510973 @default.
- W2121554658 cites W1971607019 @default.
- W2121554658 cites W1976968085 @default.
- W2121554658 cites W1977811875 @default.
- W2121554658 cites W1978502066 @default.
- W2121554658 cites W1981621010 @default.
- W2121554658 cites W1982449679 @default.
- W2121554658 cites W1986595047 @default.
- W2121554658 cites W1987464002 @default.
- W2121554658 cites W1991535764 @default.
- W2121554658 cites W1994285313 @default.
- W2121554658 cites W2004445343 @default.
- W2121554658 cites W2019229253 @default.
- W2121554658 cites W2025054356 @default.
- W2121554658 cites W2028543273 @default.
- W2121554658 cites W2032051961 @default.
- W2121554658 cites W2032625959 @default.
- W2121554658 cites W2033284482 @default.
- W2121554658 cites W2039824179 @default.
- W2121554658 cites W2047839022 @default.
- W2121554658 cites W2049958069 @default.
- W2121554658 cites W2059378220 @default.
- W2121554658 cites W2062065025 @default.
- W2121554658 cites W2070427174 @default.
- W2121554658 cites W2072362992 @default.
- W2121554658 cites W2075515301 @default.
- W2121554658 cites W2077547257 @default.
- W2121554658 cites W2077806591 @default.
- W2121554658 cites W2083239573 @default.
- W2121554658 cites W2087786585 @default.
- W2121554658 cites W2090859832 @default.
- W2121554658 cites W2092167465 @default.
- W2121554658 cites W2093994917 @default.
- W2121554658 cites W2099249565 @default.
- W2121554658 cites W2104962692 @default.
- W2121554658 cites W2107277218 @default.
- W2121554658 cites W2109642191 @default.
- W2121554658 cites W2114389372 @default.
- W2121554658 cites W2119208855 @default.
- W2121554658 cites W2125987139 @default.
- W2121554658 cites W2129605816 @default.
- W2121554658 cites W2135086442 @default.
- W2121554658 cites W2150510319 @default.
- W2121554658 cites W2153149309 @default.
- W2121554658 cites W2168579634 @default.
- W2121554658 cites W2410788664 @default.
- W2121554658 cites W2885722355 @default.
- W2121554658 doi "https://doi.org/10.1371/journal.pone.0027925" @default.
- W2121554658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3220701" @default.
- W2121554658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22125639" @default.
- W2121554658 hasPublicationYear "2011" @default.
- W2121554658 type Work @default.
- W2121554658 sameAs 2121554658 @default.
- W2121554658 citedByCount "69" @default.
- W2121554658 countsByYear W21215546582012 @default.
- W2121554658 countsByYear W21215546582013 @default.
- W2121554658 countsByYear W21215546582014 @default.
- W2121554658 countsByYear W21215546582015 @default.
- W2121554658 countsByYear W21215546582016 @default.
- W2121554658 countsByYear W21215546582017 @default.
- W2121554658 countsByYear W21215546582018 @default.
- W2121554658 countsByYear W21215546582019 @default.
- W2121554658 countsByYear W21215546582020 @default.
- W2121554658 countsByYear W21215546582021 @default.
- W2121554658 countsByYear W21215546582022 @default.
- W2121554658 countsByYear W21215546582023 @default.
- W2121554658 crossrefType "journal-article" @default.
- W2121554658 hasAuthorship W2121554658A5024072918 @default.
- W2121554658 hasAuthorship W2121554658A5057349948 @default.
- W2121554658 hasAuthorship W2121554658A5069750818 @default.
- W2121554658 hasAuthorship W2121554658A5078662901 @default.
- W2121554658 hasAuthorship W2121554658A5091186278 @default.
- W2121554658 hasBestOaLocation W21215546581 @default.
- W2121554658 hasConcept C104317684 @default.
- W2121554658 hasConcept C107459253 @default.
- W2121554658 hasConcept C126322002 @default.
- W2121554658 hasConcept C145103041 @default.
- W2121554658 hasConcept C169760540 @default.
- W2121554658 hasConcept C201750760 @default.
- W2121554658 hasConcept C203014093 @default.
- W2121554658 hasConcept C2776985911 @default.
- W2121554658 hasConcept C2778609137 @default.
- W2121554658 hasConcept C2779055221 @default.