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- W2121569286 abstract "Objective(s) Shark Liver Oil (SLO) is an immunomodulator. Macrophages play a key role in host defense against pathogens like fungi. Candida albicans have mechanisms to escape immune system. We determined the effect of killed-Candida on the in vitro viability of macrophages and the effect of SLO on augmentation of this potency. Materials and Methods Peritoneal macrophages were separated and cultured (3×10 5 /well). At first, the effect of killed-Candida (200 cells/well) on macrophage viability was evaluated, using MTT test. Then, MTT was performed on macrophages stimulated with killed-Candida in the presence of SLO. Results Killed-Candida suppressed the ability of MTT reduction and hence macrophages viability (P=0.026), but addition of SLO (100 mg/ml) significantly enhanced cell viability (P=0.00). So, SLO could neutralize the inhibitory effect of Candida. Conclusion Simultaneous with cytotoxic effect of killed-Candida cells on macrophages viability, SLO augment macrophages viability. So, it can be applied in candidiasis as a complement." @default.
- W2121569286 created "2016-06-24" @default.
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- W2121569286 date "2009-07-01" @default.
- W2121569286 modified "2023-09-26" @default.
- W2121569286 title "Effect of Shark Liver Oil on Peritoneal Murine Macrophages in Responses to Killed-Candida albicans" @default.
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- W2121569286 doi "https://doi.org/10.22038/ijbms.2009.5180" @default.
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