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• W2121570462 abstract "The effects of nicotine and 1,1-dimethyl-4-phenylpiperazinium (DMPP) on the release of newly synthesized [3H]acetylcholine in mouse cerebral cortical synaptosomes were examined. Nicotine and DMPP produced increases in [3H]acetylcholine release, over the level of spontaneous release, of 24% and 30%, respectively, of a maximum depolarization-induced release produced by 50 mM potassium. The maximum effect was achieved at a concentration of 1 X 10(-4) M for both agents. The time course of release indicated a slow onset of action, reaching a maximum effect at 15 min of incubation. Both nicotine and DMPP also produced a slightly greater release of total tritium, measured in the absence of cholinesterase inhibition, than of [3H]acetylcholine. The release induced by nicotine was completely antagonized by hexamethonium and was largely (58%) calcium-dependent. Nicotine also produced an increase in [3H]choline accumulation into synaptosomes. These results indicate that the nicotinic agonists nicotine and DMPP can produce a moderate enhancement of acetylcholine release by a receptor-mediated action on cholinergic nerve terminals in the central nervous system." @default.
• W2121570462 created "2016-06-24" @default.
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• W2121570462 date "1984-12-01" @default.
• W2121570462 modified "2023-10-12" @default.
• W2121570462 title "Nicotinic Stimulation of [³H]Acetylcholine Release from Mouse Cerebral Cortical Synaptosomes" @default.
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• W2121570462 doi "https://doi.org/10.1111/j.1471-4159.1984.tb06083.x" @default.
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