FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121572821> ?p ?o ?g. }

• W2121572821 endingPage "7325" @default.
• W2121572821 startingPage "7314" @default.
• W2121572821 abstract "B lymphocytes producing high-affinity Abs are critical for protection from extracellular pathogens, such as bacteria and parasites. The process by which high-affinity B cells are selected during the immune response has never been elucidated. Although it has been shown that high-affinity cells directly outcompete low-affinity cells in the germinal center (GC), whether there are also intrinsic differences between these cells has not been addressed. It could be that higher affinity cells proliferate more rapidly or are more likely to enter cell cycle, thereby outgrowing lower affinity cells. Alternatively, higher affinity cells could be relatively more resistant to cell death in the GC. By comparing high- and low-affinity B cells for the same Ag, we show here that low-affinity cells have an intrinsically higher death rate than do cells of higher affinity, even in the absence of competition. This suggests that selection in the GC reaction is due at least in part to the control of survival of higher affinity B cells and not by a proliferative advantage conferred upon these cells compared with lower affinity B cells. Control over survival rather than proliferation of low- and high-affinity B cells in the GC allows greater diversity not only in the primary response but also in the memory response." @default.
• W2121572821 created "2016-06-24" @default.
• W2121572821 creator A5007105182 @default.
• W2121572821 creator A5050895183 @default.
• W2121572821 creator A5057060353 @default.
• W2121572821 creator A5060038819 @default.
• W2121572821 creator A5066562919 @default.
• W2121572821 creator A5080114183 @default.
• W2121572821 creator A5083239943 @default.
• W2121572821 creator A5088058783 @default.
• W2121572821 date "2009-12-01" @default.
• W2121572821 modified "2023-10-16" @default.
• W2121572821 title "Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells" @default.
• W2121572821 cites W1509040386 @default.
• W2121572821 cites W1585376026 @default.
• W2121572821 cites W1603729648 @default.
• W2121572821 cites W1806946083 @default.
• W2121572821 cites W1830629416 @default.
• W2121572821 cites W1835619594 @default.
• W2121572821 cites W1889141895 @default.
• W2121572821 cites W1912803601 @default.
• W2121572821 cites W1924774399 @default.
• W2121572821 cites W1965770413 @default.
• W2121572821 cites W1969884610 @default.
• W2121572821 cites W1971261635 @default.
• W2121572821 cites W1975431323 @default.
• W2121572821 cites W1976759658 @default.
• W2121572821 cites W1978878058 @default.
• W2121572821 cites W1979313025 @default.
• W2121572821 cites W1982289564 @default.
• W2121572821 cites W1984940660 @default.
• W2121572821 cites W1987962683 @default.
• W2121572821 cites W1988901043 @default.
• W2121572821 cites W1989134497 @default.
• W2121572821 cites W1991497659 @default.
• W2121572821 cites W1999985136 @default.
• W2121572821 cites W2006098333 @default.
• W2121572821 cites W2014113929 @default.
• W2121572821 cites W2016721074 @default.
• W2121572821 cites W2021153432 @default.
• W2121572821 cites W2021597697 @default.
• W2121572821 cites W2022900996 @default.
• W2121572821 cites W2030816309 @default.
• W2121572821 cites W2036513424 @default.
• W2121572821 cites W2037355374 @default.
• W2121572821 cites W2041349963 @default.
• W2121572821 cites W2047206208 @default.
• W2121572821 cites W2048907294 @default.
• W2121572821 cites W2056583190 @default.
• W2121572821 cites W2057871088 @default.
• W2121572821 cites W2058311887 @default.
• W2121572821 cites W2064711508 @default.
• W2121572821 cites W2065999414 @default.
• W2121572821 cites W2068747743 @default.
• W2121572821 cites W2069667446 @default.
• W2121572821 cites W2069784383 @default.
• W2121572821 cites W2079633218 @default.
• W2121572821 cites W2079639446 @default.
• W2121572821 cites W2081719515 @default.
• W2121572821 cites W2089293301 @default.
• W2121572821 cites W2091085026 @default.
• W2121572821 cites W2100761378 @default.
• W2121572821 cites W2105336865 @default.
• W2121572821 cites W2108914304 @default.
• W2121572821 cites W2109009659 @default.
• W2121572821 cites W2114530090 @default.
• W2121572821 cites W2115291391 @default.
• W2121572821 cites W2118037954 @default.
• W2121572821 cites W2122874647 @default.
• W2121572821 cites W2123866902 @default.
• W2121572821 cites W2137206510 @default.
• W2121572821 cites W2139249955 @default.
• W2121572821 cites W2144208130 @default.
• W2121572821 cites W2149156763 @default.
• W2121572821 cites W2154049969 @default.
• W2121572821 cites W2157740207 @default.
• W2121572821 cites W2160971029 @default.
• W2121572821 cites W2164418313 @default.
• W2121572821 cites W2165197737 @default.
• W2121572821 cites W2165608602 @default.
• W2121572821 cites W2169156878 @default.
• W2121572821 cites W2171179852 @default.
• W2121572821 cites W40267425 @default.
• W2121572821 cites W4213085061 @default.
• W2121572821 cites W4232585700 @default.
• W2121572821 cites W4251633039 @default.
• W2121572821 doi "https://doi.org/10.4049/jimmunol.0902452" @default.
• W2121572821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4106706" @default.
• W2121572821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19917681" @default.
• W2121572821 hasPublicationYear "2009" @default.
• W2121572821 type Work @default.
• W2121572821 sameAs 2121572821 @default.
• W2121572821 citedByCount "87" @default.
• W2121572821 countsByYear W21215728212012 @default.
• W2121572821 countsByYear W21215728212013 @default.
• W2121572821 countsByYear W21215728212014 @default.
• W2121572821 countsByYear W21215728212015 @default.
• W2121572821 countsByYear W21215728212016 @default.

• next