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• W2121588987 abstract "Background/Aims Most patients with acute viral hepatitis A have a favorable course, but a few of them suffer from severe forms of hepatitis such as fulminant hepatitis. This study was carried out to identify the factors influencing the severity of acute viral hepatitis A. Methods We retrospectively reviewed the medical records of 713 patients with acute hepatitis A, who were divided into two groups: severe hepatitis A (N=87) and non-severe hepatitis A (N=626). Severe hepatitis was defined as fulminant hepatitis or prolongation of prothrombin time (INR≥1.5). Clinical variables were compared between the two groups. Results The incidence of fulminant hepatitis was 1.4% (10/713) in patients with acute hepatitis A. Thirty-three (4.6%) cases exhibited HBsAg positivity. In multivariate analyses, significant alcohol intake and the presence of HBsAg were significant predictive factors of fulminant hepatitis A, and significant alcohol intake and age were significant predictive factors of severe hepatitis A. HBeAg and HBV-DNA status did not affect the clinical course of hepatitis A in chronic hepatitis B carriers. Conclusions While most patients with acute hepatitis A have an uncomplicated clinical course, our data suggest that a more-severe clinical course is correlated with being older, significant alcohol intake, and chronic hepatitis-B-virus infection. Keywords: Hepatitis A; Severity; Liver failure; Fulminant" @default.
• W2121588987 created "2016-06-24" @default.
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• W2121588987 date "2010-01-01" @default.
• W2121588987 modified "2023-10-04" @default.
• W2121588987 title "Factors influencing the severity of acute viral hepatitis A" @default.
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• W2121588987 doi "https://doi.org/10.3350/kjhep.2010.16.3.295" @default.
• W2121588987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3304596" @default.
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