FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121630812> ?p ?o ?g. }

• W2121630812 endingPage "23" @default.
• W2121630812 startingPage "17" @default.
• W2121630812 abstract "Abstract A three‐stage approach was undertaken using genome‐wide, case‐control, and case‐only association studies to identify genetic variants associated with heart failure mortality. In an Amish founder population ( n = 851), cardiac hypertrophy, a trait integral to the adaptive response to failure, was found to be heritable ( h 2 = 0.28, p = 0.0002) and GWAS revealed 21 candidate hypertrophy SNPs. In a case ( n = 1,610)‐control ( n = 463) study in unrelated Caucasians, one of the SNPs associated with hypertrophy (rs2207418, p = 8 × 10 −6 ), was associated with heart failure, RR = 1.85(1.25–2.73, p = 0.0019). In heart failure cases rs2207418 was associated with increased mortality, HR = 1.51(1.20–1.97, p = 0.0004). There was consistency between studies, with the GG allele being associated with increased ventricular mass (˜13 g/m 2 ) in the Amish, heart failure risk, and heart failure mortality. This SNP is in a gene desert of chromosome 20p12. Five genes are within 2.0 mbp of rs2207418 but with low LD between their SNPs and rs2207418. A region near this SNP is highly conserved in multiple vertebrates (lod score = 1,208). This conservation and the internal consistency across studies suggests that this region has biologic importance in heart failure, potentially acting as an enhancer or repressor element. rs2207418 may be useful for predicting a more progressive form of heart failure that may require aggressive therapy. Clin Trans Sci 2011; Volume 4: 17–23" @default.
• W2121630812 created "2016-06-24" @default.
• W2121630812 creator A5000209385 @default.
• W2121630812 creator A5002993711 @default.
• W2121630812 creator A5017178370 @default.
• W2121630812 creator A5024158146 @default.
• W2121630812 creator A5032058628 @default.
• W2121630812 creator A5033395571 @default.
• W2121630812 creator A5042121948 @default.
• W2121630812 creator A5071683394 @default.
• W2121630812 creator A5080323020 @default.
• W2121630812 creator A5084616864 @default.
• W2121630812 date "2011-02-01" @default.
• W2121630812 modified "2023-10-18" @default.
• W2121630812 title "Hypertrophy-Associated Polymorphisms Ascertained in a Founder Cohort Applied to Heart Failure Risk and Mortality" @default.
• W2121630812 cites W1572876008 @default.
• W2121630812 cites W1973619956 @default.
• W2121630812 cites W1974581186 @default.
• W2121630812 cites W2004652696 @default.
• W2121630812 cites W2005104619 @default.
• W2121630812 cites W2021458745 @default.
• W2121630812 cites W2025389038 @default.
• W2121630812 cites W2031291916 @default.
• W2121630812 cites W2032167303 @default.
• W2121630812 cites W2042293234 @default.
• W2121630812 cites W2050388132 @default.
• W2121630812 cites W2070551632 @default.
• W2121630812 cites W2086895688 @default.
• W2121630812 cites W2110624042 @default.
• W2121630812 cites W2113829561 @default.
• W2121630812 cites W2115335486 @default.
• W2121630812 cites W2120936186 @default.
• W2121630812 cites W2129723021 @default.
• W2121630812 cites W2141561295 @default.
• W2121630812 cites W2145191876 @default.
• W2121630812 cites W2162530578 @default.
• W2121630812 cites W2171167177 @default.
• W2121630812 cites W2171515161 @default.
• W2121630812 cites W2289352020 @default.
• W2121630812 cites W2334499091 @default.
• W2121630812 doi "https://doi.org/10.1111/j.1752-8062.2010.00251.x" @default.
• W2121630812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4373555" @default.
• W2121630812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21348951" @default.
• W2121630812 hasPublicationYear "2011" @default.
• W2121630812 type Work @default.
• W2121630812 sameAs 2121630812 @default.
• W2121630812 citedByCount "34" @default.
• W2121630812 countsByYear W21216308122012 @default.
• W2121630812 countsByYear W21216308122013 @default.
• W2121630812 countsByYear W21216308122015 @default.
• W2121630812 countsByYear W21216308122016 @default.
• W2121630812 countsByYear W21216308122017 @default.
• W2121630812 countsByYear W21216308122018 @default.
• W2121630812 countsByYear W21216308122019 @default.
• W2121630812 countsByYear W21216308122020 @default.
• W2121630812 countsByYear W21216308122021 @default.
• W2121630812 crossrefType "journal-article" @default.
• W2121630812 hasAuthorship W2121630812A5000209385 @default.
• W2121630812 hasAuthorship W2121630812A5002993711 @default.
• W2121630812 hasAuthorship W2121630812A5017178370 @default.
• W2121630812 hasAuthorship W2121630812A5024158146 @default.
• W2121630812 hasAuthorship W2121630812A5032058628 @default.
• W2121630812 hasAuthorship W2121630812A5033395571 @default.
• W2121630812 hasAuthorship W2121630812A5042121948 @default.
• W2121630812 hasAuthorship W2121630812A5071683394 @default.
• W2121630812 hasAuthorship W2121630812A5080323020 @default.
• W2121630812 hasAuthorship W2121630812A5084616864 @default.
• W2121630812 hasBestOaLocation W21216308121 @default.
• W2121630812 hasConcept C104317684 @default.
• W2121630812 hasConcept C106208931 @default.
• W2121630812 hasConcept C126322002 @default.
• W2121630812 hasConcept C135763542 @default.
• W2121630812 hasConcept C139275648 @default.
• W2121630812 hasConcept C153209595 @default.
• W2121630812 hasConcept C164705383 @default.
• W2121630812 hasConcept C2778198053 @default.
• W2121630812 hasConcept C2908647359 @default.
• W2121630812 hasConcept C54355233 @default.
• W2121630812 hasConcept C69991583 @default.
• W2121630812 hasConcept C71924100 @default.
• W2121630812 hasConcept C86803240 @default.
• W2121630812 hasConcept C99454951 @default.
• W2121630812 hasConceptScore W2121630812C104317684 @default.
• W2121630812 hasConceptScore W2121630812C106208931 @default.
• W2121630812 hasConceptScore W2121630812C126322002 @default.
• W2121630812 hasConceptScore W2121630812C135763542 @default.
• W2121630812 hasConceptScore W2121630812C139275648 @default.
• W2121630812 hasConceptScore W2121630812C153209595 @default.
• W2121630812 hasConceptScore W2121630812C164705383 @default.
• W2121630812 hasConceptScore W2121630812C2778198053 @default.
• W2121630812 hasConceptScore W2121630812C2908647359 @default.
• W2121630812 hasConceptScore W2121630812C54355233 @default.
• W2121630812 hasConceptScore W2121630812C69991583 @default.
• W2121630812 hasConceptScore W2121630812C71924100 @default.
• W2121630812 hasConceptScore W2121630812C86803240 @default.
• W2121630812 hasConceptScore W2121630812C99454951 @default.
• W2121630812 hasIssue "1" @default.
• W2121630812 hasLocation W21216308121 @default.

• next