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- W2121640810 abstract "Raman spectroscopy using surfaceenhanced Raman scattering (SERS) nanoparticles is an exciting new molecular imaging modality that has emerged over the past decade [1,2]. The approach is based on the inelastic scatter of photons by molecular bonds. Small-molecule dyes adsorbed on a rough metal (usually gold) surface experience a dramatic increase in their Raman scatter intensity due to surface plasmons, which induce strong localized electric fields near the surface [3]. As each bond within a Raman dye has a characteristic vibrational energy, the SERS spectrum is unique for that dye. The nanoparticle for Raman molecular imaging is composed of: a gold core to provide the signal enhancement, an adsorbed dye to provide the SERS spectrum, a biocompatible coating (e.g., polyethylene glycol or silica) and a targeting moiety (e.g., an antibody). By combining unique dye spectra and targeting moieties for different biological targets, highsensitivity, multiplexed molecular imaging is possible in vivo with an environmentally and optically stable contrast agent [4–8]. Summarized below are four exciting recent reports that significantly advance the field of SERS-based molecular imaging." @default.
- W2121640810 created "2016-06-24" @default.
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- W2121640810 date "2013-02-01" @default.
- W2121640810 modified "2023-09-27" @default.
- W2121640810 title "Research Highlights: Highlights from the latest articles on molecular imaging with Raman spectroscopy" @default.
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- W2121640810 doi "https://doi.org/10.2217/iim.12.66" @default.
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