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• W2121710010 abstract "Standardized criteria for assessing response are essential to ensure comparability among clinical trials for patients with myelodysplastic syndromes (MDS). An international working group of experienced clinicians involved in the management of patients with MDS reviewed currently used response definitions and developed a uniform set of guidelines for future clinical trials in MDS. The MDS differ from many other hematologic malignancies in their chronicity and the morbidity and mortality caused by chronic cytopenias, often without disease progression to acute myeloid leukemia. Whereas response rates may be an important endpoint for phase 2 studies of new agents and may assist regulatory agencies in their evaluation and approval processes, an important goal of clinical trials in MDS should be to prolong patient survival. Therefore, these response criteria reflected 2 sets of goals in MDS: altering the natural history of the disease and alleviating disease-related complications with improved quality of life. It is anticipated that the recommendations presented will require modification as more is learned about the molecular biology and genetics of these disorders. Until then, it is hoped these guidelines will serve to improve communication among investigators and to ensure comparability among clinical trials. (Blood. 2000;96:3671-3674)" @default.
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• W2121710010 date "2000-12-01" @default.
• W2121710010 modified "2023-10-17" @default.
• W2121710010 title "Report of an international working group to standardize response criteria for myelodysplastic syndromes" @default.
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• W2121710010 doi "https://doi.org/10.1182/blood.v96.12.3671" @default.
• W2121710010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11090046" @default.
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