FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121735257> ?p ?o ?g. }

• W2121735257 endingPage "136" @default.
• W2121735257 startingPage "136" @default.
• W2121735257 abstract "Background: Despite of aggressive treatments, the long-term survival rate is about 30% in stage 4 neuroblastoma (NBL). Recently, dendritic cell (DC)-based immunotherapy is emerging as a promising tool in cancer treatment. But it is very difficult to get sufficient amount of autologous tumor as the source of tumor antigen in DC-based immunotherapy. The purpose of this study was to test whether DCs loaded with allogeneic NBL tumor antigens can prime effective antitumor immune responses. Methods: Peripheral blood mononuclear cells (PBMCs) were differentiated into immature DCs in the presence of GM-CSF and IL-4. As the source of tumor antigens, human neuroblastoma cell lines, SK-N-MC, SK-N-SH, and IMR-32, were used after induction of apoptosis by UV irradiation. The immature DCs were loaded with apoptotic tumor cells, and then cultured with PBMCs for priming the tumor antigen-specific T lymphocytes. The tumor-specific cytotoxicity of T lymphocytes against NBL cells was analysed after coculture. Results: Incubation of DCs with apoptotic tumor cells effectively loaded DCs with tumor antigens and induced maturation of DCs. The tumor antigen-challenged T lymphocytes effectively killed the NBL cells, which were used as tumor antigens. Furthermore, the T lymphocytes showed a broad ranged cytotoxicity to all of the NBL cell lines, which were not challenged as tumor antigens. Conclusion: This study showed that the apoptotic NBL tumor cells induced maturation of DCs and could be used as tumor antigens, and DCs loaded with apoptotic NBL tumor cells could induce effective antitumor specific cytotoxic T lymphocytes to allogeneic NBL tumors." @default.
• W2121735257 created "2016-06-24" @default.
• W2121735257 creator A5009699134 @default.
• W2121735257 creator A5057522489 @default.
• W2121735257 creator A5073690360 @default.
• W2121735257 date "2007-01-01" @default.
• W2121735257 modified "2023-10-01" @default.
• W2121735257 title "Anti-tumor Cytotoxicity of Allogeneic Neuroblastoma Tumor Antigen-loaded Dendiritic Cells" @default.
• W2121735257 cites W1554669092 @default.
• W2121735257 cites W1558813989 @default.
• W2121735257 cites W1661544713 @default.
• W2121735257 cites W1852330431 @default.
• W2121735257 cites W1982732144 @default.
• W2121735257 cites W1993149812 @default.
• W2121735257 cites W2002517161 @default.
• W2121735257 cites W2039990819 @default.
• W2121735257 cites W2049834113 @default.
• W2121735257 cites W2069943687 @default.
• W2121735257 cites W2084630090 @default.
• W2121735257 cites W2086135567 @default.
• W2121735257 cites W2088890805 @default.
• W2121735257 cites W2090890051 @default.
• W2121735257 cites W2096869493 @default.
• W2121735257 cites W2098290847 @default.
• W2121735257 cites W2115439647 @default.
• W2121735257 cites W2117216774 @default.
• W2121735257 cites W2119817247 @default.
• W2121735257 cites W2127982431 @default.
• W2121735257 cites W2151939400 @default.
• W2121735257 cites W2164907614 @default.
• W2121735257 cites W2474308075 @default.
• W2121735257 doi "https://doi.org/10.5045/kjh.2007.42.2.136" @default.
• W2121735257 hasPublicationYear "2007" @default.
• W2121735257 type Work @default.
• W2121735257 sameAs 2121735257 @default.
• W2121735257 citedByCount "0" @default.
• W2121735257 crossrefType "journal-article" @default.
• W2121735257 hasAuthorship W2121735257A5009699134 @default.
• W2121735257 hasAuthorship W2121735257A5057522489 @default.
• W2121735257 hasAuthorship W2121735257A5073690360 @default.
• W2121735257 hasBestOaLocation W21217352571 @default.
• W2121735257 hasConcept C100701293 @default.
• W2121735257 hasConcept C109316439 @default.
• W2121735257 hasConcept C137061746 @default.
• W2121735257 hasConcept C147483822 @default.
• W2121735257 hasConcept C154317977 @default.
• W2121735257 hasConcept C190283241 @default.
• W2121735257 hasConcept C202751555 @default.
• W2121735257 hasConcept C203014093 @default.
• W2121735257 hasConcept C2776662205 @default.
• W2121735257 hasConcept C2776715637 @default.
• W2121735257 hasConcept C2777701055 @default.
• W2121735257 hasConcept C502942594 @default.
• W2121735257 hasConcept C54355233 @default.
• W2121735257 hasConcept C55493867 @default.
• W2121735257 hasConcept C59822182 @default.
• W2121735257 hasConcept C71924100 @default.
• W2121735257 hasConcept C81444415 @default.
• W2121735257 hasConcept C81885089 @default.
• W2121735257 hasConcept C86803240 @default.
• W2121735257 hasConcept C8891405 @default.
• W2121735257 hasConceptScore W2121735257C100701293 @default.
• W2121735257 hasConceptScore W2121735257C109316439 @default.
• W2121735257 hasConceptScore W2121735257C137061746 @default.
• W2121735257 hasConceptScore W2121735257C147483822 @default.
• W2121735257 hasConceptScore W2121735257C154317977 @default.
• W2121735257 hasConceptScore W2121735257C190283241 @default.
• W2121735257 hasConceptScore W2121735257C202751555 @default.
• W2121735257 hasConceptScore W2121735257C203014093 @default.
• W2121735257 hasConceptScore W2121735257C2776662205 @default.
• W2121735257 hasConceptScore W2121735257C2776715637 @default.
• W2121735257 hasConceptScore W2121735257C2777701055 @default.
• W2121735257 hasConceptScore W2121735257C502942594 @default.
• W2121735257 hasConceptScore W2121735257C54355233 @default.
• W2121735257 hasConceptScore W2121735257C55493867 @default.
• W2121735257 hasConceptScore W2121735257C59822182 @default.
• W2121735257 hasConceptScore W2121735257C71924100 @default.
• W2121735257 hasConceptScore W2121735257C81444415 @default.
• W2121735257 hasConceptScore W2121735257C81885089 @default.
• W2121735257 hasConceptScore W2121735257C86803240 @default.
• W2121735257 hasConceptScore W2121735257C8891405 @default.
• W2121735257 hasIssue "2" @default.
• W2121735257 hasLocation W21217352571 @default.
• W2121735257 hasOpenAccess W2121735257 @default.
• W2121735257 hasPrimaryLocation W21217352571 @default.
• W2121735257 hasRelatedWork W2022517847 @default.
• W2121735257 hasRelatedWork W2023706105 @default.
• W2121735257 hasRelatedWork W2083428302 @default.
• W2121735257 hasRelatedWork W2126367104 @default.
• W2121735257 hasRelatedWork W2126966733 @default.
• W2121735257 hasRelatedWork W2144548733 @default.
• W2121735257 hasRelatedWork W2187248412 @default.
• W2121735257 hasRelatedWork W2220102944 @default.
• W2121735257 hasRelatedWork W2389756890 @default.
• W2121735257 hasRelatedWork W1988261318 @default.
• W2121735257 hasVolume "42" @default.
• W2121735257 isParatext "false" @default.
• W2121735257 isRetracted "false" @default.

• next