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• W2121750478 abstract "We have performed direct electrophysiological recordings from Drosophila peptidergic synaptic boutons in situ , taking advantage of a mutation, ecdysone , which causes an increase in size of these terminals. Using patch-clamp techniques, we have analyzed voltage-dependent potassium currents at the macroscopic and single-channel level. The synaptic membrane contained at least two distinct voltage-activated potassium currents with different kinetics and voltage sensitivity: an I A -like current with fast activation and inactivation kinetics and voltage-dependent steady-state inactivation; a complex delayed current that includes a slowly inactivating component, resembling the I K described in other preparations; and a noninactivating component. The I A -like current in these peptidergic boutons is not encoded by the gene Shaker , because it is not affected by null mutations at this locus. Rather, synaptic I A has properties similar to those of the Shal -encoded I A . Single-channel recordings revealed the presence in synaptic membranes of three different potassium channel types (A 2 , K D , K L ), with biophysical properties that could account for the macroscopic currents and resemble those of the Shal , Shab , and Shaw channels described in heterologous expression systems and Drosophila neuronal somata. A 2 channels (6–9 pS) have brief open times, and like the macroscopic I A they exhibited voltage-dependent steady-state inactivation and a rapidly inactivating ensemble average current profile. K D channels (13–16 pS) had longer open times, activate and inactivate with much slower kinetics, and may account for the slowly inactivating component of the macroscopic current. K L (44–54 pS) channels produced a noninactivating ensemble average and may contribute to the delayed macroscopic current observed." @default.
• W2121750478 created "2016-06-24" @default.
• W2121750478 creator A5020451832 @default.
• W2121750478 creator A5076186098 @default.
• W2121750478 date "1997-05-15" @default.
• W2121750478 modified "2023-09-27" @default.
• W2121750478 title "Presynaptic Recordings from<i>Drosophila</i>: Correlatin of Macroscopic and Single-Channel K⁺Currents" @default.
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• W2121750478 doi "https://doi.org/10.1523/jneurosci.17-10-03412.1997" @default.
• W2121750478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573676" @default.
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