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• W2121754708 startingPage "2840" @default.
• W2121754708 abstract "Endometrial cancer is the most common gynecologic malignancy in the United States. Substantial epidemiologic data implicate an imbalance of estrogens and progestogens in the etiology of this disease. We propose that inflammation also plays a role in endometrial cancer development. Emerging laboratory data suggest that elevated levels of prostaglandin E(2) may underlie the transformation of normal endometrium to neoplastic tissue and that in vitro nonsteroidal anti-inflammatory drugs may inhibit endometrial cancer cell growth. In this review, we suggest that the risk factors for endometrial cancer--unopposed estrogens, anovulation, polycystic ovary syndrome, excessive menstruation, early menarche, and late menopause--may be viewed as factors increasing the exposure of the endometrium to inflammation, whereas pregnancy and smoking, two likely protective factors, have the opposite effect. Chronic inflammation can induce rapid cell division, increasing the possibility for replication error, ineffective DNA repair, and subsequent mutations. A proinflammatory milieu can also directly increase estrogen production. Hence, inflammation may work in conjunction with or in addition to estrogen exposure in the development of endometrial cancer." @default.
• W2121754708 created "2016-06-24" @default.
• W2121754708 creator A5016958524 @default.
• W2121754708 creator A5052136481 @default.
• W2121754708 creator A5069531414 @default.
• W2121754708 creator A5076251961 @default.
• W2121754708 date "2005-12-01" @default.
• W2121754708 modified "2023-10-16" @default.
• W2121754708 title "Inflammation and Endometrial Cancer: A Hypothesis" @default.
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