Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121781131> ?p ?o ?g. }
- W2121781131 endingPage "173" @default.
- W2121781131 startingPage "157" @default.
- W2121781131 abstract "Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and mechanotransduction. Major uncertainties concern the sufficiency of talin for activation, whether conformational change without clustering leads to activation, and whether mechanical force is required for molecular extension. Here, we reconstructed physiological integrin activation in vitro and used cellular, biochemical, biophysical, and ultrastructural analyses to show that talin binding is sufficient to activate integrin αIIbβ3. Furthermore, we synthesized nanodiscs, each bearing a single lipid-embedded integrin, and used them to show that talin activates unclustered integrins leading to molecular extension in the absence of force or other membrane proteins. Thus, we provide the first proof that talin binding is sufficient to activate and extend membrane-embedded integrin αIIbβ3, thereby resolving numerous controversies and enabling molecular analysis of reconstructed integrin signaling." @default.
- W2121781131 created "2016-06-24" @default.
- W2121781131 creator A5032907445 @default.
- W2121781131 creator A5036141472 @default.
- W2121781131 creator A5050311492 @default.
- W2121781131 creator A5050815439 @default.
- W2121781131 creator A5061307357 @default.
- W2121781131 creator A5067273795 @default.
- W2121781131 creator A5068260507 @default.
- W2121781131 creator A5071061402 @default.
- W2121781131 creator A5081446055 @default.
- W2121781131 date "2010-01-04" @default.
- W2121781131 modified "2023-10-18" @default.
- W2121781131 title "Recreation of the terminal events in physiological integrin activation" @default.
- W2121781131 cites W1500795239 @default.
- W2121781131 cites W1501072984 @default.
- W2121781131 cites W1506821897 @default.
- W2121781131 cites W1564480961 @default.
- W2121781131 cites W1571377358 @default.
- W2121781131 cites W1576773659 @default.
- W2121781131 cites W1601529928 @default.
- W2121781131 cites W1602182436 @default.
- W2121781131 cites W1646794664 @default.
- W2121781131 cites W1656991593 @default.
- W2121781131 cites W1938388466 @default.
- W2121781131 cites W1966086272 @default.
- W2121781131 cites W1968443620 @default.
- W2121781131 cites W1968690892 @default.
- W2121781131 cites W1973800056 @default.
- W2121781131 cites W1977283446 @default.
- W2121781131 cites W1978702162 @default.
- W2121781131 cites W1985597303 @default.
- W2121781131 cites W1986476951 @default.
- W2121781131 cites W1993886672 @default.
- W2121781131 cites W1994331544 @default.
- W2121781131 cites W1995553619 @default.
- W2121781131 cites W1996880045 @default.
- W2121781131 cites W1998539678 @default.
- W2121781131 cites W1999765951 @default.
- W2121781131 cites W2005574282 @default.
- W2121781131 cites W2006158980 @default.
- W2121781131 cites W2009428466 @default.
- W2121781131 cites W2012691080 @default.
- W2121781131 cites W2013841398 @default.
- W2121781131 cites W2014886554 @default.
- W2121781131 cites W2015616869 @default.
- W2121781131 cites W2016952508 @default.
- W2121781131 cites W2017351873 @default.
- W2121781131 cites W2019133761 @default.
- W2121781131 cites W2021855648 @default.
- W2121781131 cites W2024616958 @default.
- W2121781131 cites W2028305453 @default.
- W2121781131 cites W2029201535 @default.
- W2121781131 cites W2039453220 @default.
- W2121781131 cites W2040379229 @default.
- W2121781131 cites W2043560354 @default.
- W2121781131 cites W2046737719 @default.
- W2121781131 cites W2054110168 @default.
- W2121781131 cites W2056823255 @default.
- W2121781131 cites W2058624823 @default.
- W2121781131 cites W2061100651 @default.
- W2121781131 cites W2065921660 @default.
- W2121781131 cites W2069575222 @default.
- W2121781131 cites W2072834874 @default.
- W2121781131 cites W2074446921 @default.
- W2121781131 cites W2081401313 @default.
- W2121781131 cites W2083965774 @default.
- W2121781131 cites W2084302112 @default.
- W2121781131 cites W2088544660 @default.
- W2121781131 cites W2094469836 @default.
- W2121781131 cites W2098438673 @default.
- W2121781131 cites W2101346022 @default.
- W2121781131 cites W2101349818 @default.
- W2121781131 cites W2108496308 @default.
- W2121781131 cites W2111803487 @default.
- W2121781131 cites W2112509218 @default.
- W2121781131 cites W2114213585 @default.
- W2121781131 cites W2127170661 @default.
- W2121781131 cites W2130180308 @default.
- W2121781131 cites W2131309206 @default.
- W2121781131 cites W2138828504 @default.
- W2121781131 cites W2141643986 @default.
- W2121781131 cites W2148062709 @default.
- W2121781131 cites W2148377692 @default.
- W2121781131 cites W2154909249 @default.
- W2121781131 cites W2157012084 @default.
- W2121781131 cites W2160899469 @default.
- W2121781131 cites W2163449711 @default.
- W2121781131 cites W2165078795 @default.
- W2121781131 cites W2170877356 @default.
- W2121781131 cites W2171187567 @default.
- W2121781131 cites W2377109711 @default.
- W2121781131 cites W264187420 @default.
- W2121781131 cites W4239907137 @default.
- W2121781131 doi "https://doi.org/10.1083/jcb.200908045" @default.
- W2121781131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812850" @default.
- W2121781131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20048261" @default.
- W2121781131 hasPublicationYear "2010" @default.