Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121787035> ?p ?o ?g. }
- W2121787035 endingPage "626" @default.
- W2121787035 startingPage "617" @default.
- W2121787035 abstract "Tumor necrosis factor (TNF)-related cytokines regulate cell death and survival and provide strong selective pressures for viruses, such as cytomegalovirus (CMV), to evolve counterstrategies in order to persist in immune-competent hosts. Signaling by the lymphotoxin (LT)-beta receptor or TNF receptor-1, but not Fas or TRAIL receptors, inhibits the cytopathicity and replication of human CMV by a nonapoptotic, reversible process that requires nuclear factor kappa B (NF-kappa B)-dependent induction of interferon-beta (IFN-beta). Efficient induction of IFN-beta requires virus infection and LT signaling, demonstrating the need for both host and viral factors in the curtailment of viral replication without cellular elimination. LT alpha-deficient mice and LT beta R-Fc transgenic mice were profoundly susceptible to murine CMV infection. Together, these results reveal an essential and conserved role for LTs in establishing host defense to CMV." @default.
- W2121787035 created "2016-06-24" @default.
- W2121787035 creator A5002148348 @default.
- W2121787035 creator A5004297940 @default.
- W2121787035 creator A5010294666 @default.
- W2121787035 creator A5026851574 @default.
- W2121787035 creator A5032655460 @default.
- W2121787035 creator A5065696246 @default.
- W2121787035 creator A5069383224 @default.
- W2121787035 creator A5081754718 @default.
- W2121787035 date "2001-10-01" @default.
- W2121787035 modified "2023-10-14" @default.
- W2121787035 title "Lymphotoxins and Cytomegalovirus Cooperatively Induce Interferon-β, Establishing Host-Virus Détente" @default.
- W2121787035 cites W142428048 @default.
- W2121787035 cites W1482195803 @default.
- W2121787035 cites W1482724118 @default.
- W2121787035 cites W1492606093 @default.
- W2121787035 cites W1520292475 @default.
- W2121787035 cites W1540696654 @default.
- W2121787035 cites W1558675846 @default.
- W2121787035 cites W1566314326 @default.
- W2121787035 cites W1600236870 @default.
- W2121787035 cites W1705862960 @default.
- W2121787035 cites W1868950919 @default.
- W2121787035 cites W1890314278 @default.
- W2121787035 cites W1926282609 @default.
- W2121787035 cites W1973891072 @default.
- W2121787035 cites W1978950020 @default.
- W2121787035 cites W1980919524 @default.
- W2121787035 cites W1983125314 @default.
- W2121787035 cites W1983963541 @default.
- W2121787035 cites W1994718301 @default.
- W2121787035 cites W2003565653 @default.
- W2121787035 cites W2006281076 @default.
- W2121787035 cites W2014373584 @default.
- W2121787035 cites W2025532600 @default.
- W2121787035 cites W2029875651 @default.
- W2121787035 cites W2032514624 @default.
- W2121787035 cites W2046553655 @default.
- W2121787035 cites W2049118734 @default.
- W2121787035 cites W2050603521 @default.
- W2121787035 cites W2064537387 @default.
- W2121787035 cites W2076317085 @default.
- W2121787035 cites W2089077517 @default.
- W2121787035 cites W2090814843 @default.
- W2121787035 cites W2091478221 @default.
- W2121787035 cites W2092090684 @default.
- W2121787035 cites W2098609173 @default.
- W2121787035 cites W2099019634 @default.
- W2121787035 cites W2100195610 @default.
- W2121787035 cites W2101580628 @default.
- W2121787035 cites W2105514243 @default.
- W2121787035 cites W2113765407 @default.
- W2121787035 cites W2132507383 @default.
- W2121787035 cites W2133726754 @default.
- W2121787035 cites W2140965613 @default.
- W2121787035 cites W2143857423 @default.
- W2121787035 cites W2157861528 @default.
- W2121787035 cites W2170741917 @default.
- W2121787035 cites W2172000447 @default.
- W2121787035 cites W4313377005 @default.
- W2121787035 doi "https://doi.org/10.1016/s1074-7613(01)00222-9" @default.
- W2121787035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11672543" @default.
- W2121787035 hasPublicationYear "2001" @default.
- W2121787035 type Work @default.
- W2121787035 sameAs 2121787035 @default.
- W2121787035 citedByCount "95" @default.
- W2121787035 countsByYear W21217870352012 @default.
- W2121787035 countsByYear W21217870352013 @default.
- W2121787035 countsByYear W21217870352014 @default.
- W2121787035 countsByYear W21217870352015 @default.
- W2121787035 countsByYear W21217870352016 @default.
- W2121787035 countsByYear W21217870352017 @default.
- W2121787035 countsByYear W21217870352018 @default.
- W2121787035 countsByYear W21217870352020 @default.
- W2121787035 countsByYear W21217870352022 @default.
- W2121787035 crossrefType "journal-article" @default.
- W2121787035 hasAuthorship W2121787035A5002148348 @default.
- W2121787035 hasAuthorship W2121787035A5004297940 @default.
- W2121787035 hasAuthorship W2121787035A5010294666 @default.
- W2121787035 hasAuthorship W2121787035A5026851574 @default.
- W2121787035 hasAuthorship W2121787035A5032655460 @default.
- W2121787035 hasAuthorship W2121787035A5065696246 @default.
- W2121787035 hasAuthorship W2121787035A5069383224 @default.
- W2121787035 hasAuthorship W2121787035A5081754718 @default.
- W2121787035 hasBestOaLocation W21217870351 @default.
- W2121787035 hasConcept C102230213 @default.
- W2121787035 hasConcept C104317684 @default.
- W2121787035 hasConcept C136449434 @default.
- W2121787035 hasConcept C140704245 @default.
- W2121787035 hasConcept C159047783 @default.
- W2121787035 hasConcept C170493617 @default.
- W2121787035 hasConcept C17991360 @default.
- W2121787035 hasConcept C203014093 @default.
- W2121787035 hasConcept C2522874641 @default.
- W2121787035 hasConcept C2776178377 @default.
- W2121787035 hasConcept C2776409557 @default.
- W2121787035 hasConcept C2777732132 @default.