Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121819563> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2121819563 abstract "Cone-plate viscometry is used extensively to study platelet and neutrophil aggregation kinetics. Conventional studies assume that flow in the viscometer is linear and that the nature of cell adhesion is independent of position in the device. However, at higher shear rates centrifugal forces result in radial motion of the liquid and hence significant secondary flow. We examined how this secondary flow may alter cellular adhesion kinetics. The Navier-Stokes equation was solved numerically to determine the flow profile in the viscometer up to a shear rate (G) of 1500 s/sup -1/. These results were coupled with a theoretical analysis of two-body particle hydrodynamics to estimate how the magnitude of inter-particle forces and contact duration vary with position in the viscometer. While positional variations within the inner half region of the viscometer were small and close to that predicted by linear flow analysis, the variations were more pronounced near the edge. Increasing the shear rate and the sample volume caused an increase in secondary flow effects. A bimolecular kinetic model was applied to estimate the overall cell adhesion efficiency under these conditions. Results indicate that, secondary flow at G=1500 s/sup -1/, caused decreases in adhesion efficiency of up to 30% relative to linear flow analysis. In addition to the mathematical model, experimental validation of theoretical predictions are also presented." @default.
- W2121819563 created "2016-06-24" @default.
- W2121819563 creator A5013793470 @default.
- W2121819563 creator A5054244721 @default.
- W2121819563 date "2003-01-20" @default.
- W2121819563 modified "2023-09-27" @default.
- W2121819563 title "Cell adhesion kinetics varies with position in the cone-plate viscometer" @default.
- W2121819563 cites W2031207861 @default.
- W2121819563 cites W2069896733 @default.
- W2121819563 doi "https://doi.org/10.1109/iembs.1999.802097" @default.
- W2121819563 hasPublicationYear "2003" @default.
- W2121819563 type Work @default.
- W2121819563 sameAs 2121819563 @default.
- W2121819563 citedByCount "0" @default.
- W2121819563 crossrefType "proceedings-article" @default.
- W2121819563 hasAuthorship W2121819563A5013793470 @default.
- W2121819563 hasAuthorship W2121819563A5054244721 @default.
- W2121819563 hasConcept C121332964 @default.
- W2121819563 hasConcept C127172972 @default.
- W2121819563 hasConcept C135768490 @default.
- W2121819563 hasConcept C148898269 @default.
- W2121819563 hasConcept C159985019 @default.
- W2121819563 hasConcept C165682214 @default.
- W2121819563 hasConcept C172120300 @default.
- W2121819563 hasConcept C185592680 @default.
- W2121819563 hasConcept C19191322 @default.
- W2121819563 hasConcept C192562407 @default.
- W2121819563 hasConcept C2781424430 @default.
- W2121819563 hasConcept C38349280 @default.
- W2121819563 hasConcept C57879066 @default.
- W2121819563 hasConcept C74650414 @default.
- W2121819563 hasConcept C84416704 @default.
- W2121819563 hasConcept C93356670 @default.
- W2121819563 hasConcept C97355855 @default.
- W2121819563 hasConceptScore W2121819563C121332964 @default.
- W2121819563 hasConceptScore W2121819563C127172972 @default.
- W2121819563 hasConceptScore W2121819563C135768490 @default.
- W2121819563 hasConceptScore W2121819563C148898269 @default.
- W2121819563 hasConceptScore W2121819563C159985019 @default.
- W2121819563 hasConceptScore W2121819563C165682214 @default.
- W2121819563 hasConceptScore W2121819563C172120300 @default.
- W2121819563 hasConceptScore W2121819563C185592680 @default.
- W2121819563 hasConceptScore W2121819563C19191322 @default.
- W2121819563 hasConceptScore W2121819563C192562407 @default.
- W2121819563 hasConceptScore W2121819563C2781424430 @default.
- W2121819563 hasConceptScore W2121819563C38349280 @default.
- W2121819563 hasConceptScore W2121819563C57879066 @default.
- W2121819563 hasConceptScore W2121819563C74650414 @default.
- W2121819563 hasConceptScore W2121819563C84416704 @default.
- W2121819563 hasConceptScore W2121819563C93356670 @default.
- W2121819563 hasConceptScore W2121819563C97355855 @default.
- W2121819563 hasLocation W21218195631 @default.
- W2121819563 hasOpenAccess W2121819563 @default.
- W2121819563 hasPrimaryLocation W21218195631 @default.
- W2121819563 hasRelatedWork W161439402 @default.
- W2121819563 hasRelatedWork W1616871441 @default.
- W2121819563 hasRelatedWork W1976811810 @default.
- W2121819563 hasRelatedWork W1987994830 @default.
- W2121819563 hasRelatedWork W2010473922 @default.
- W2121819563 hasRelatedWork W2011135733 @default.
- W2121819563 hasRelatedWork W2030258314 @default.
- W2121819563 hasRelatedWork W2039196738 @default.
- W2121819563 hasRelatedWork W2049640282 @default.
- W2121819563 hasRelatedWork W2057663206 @default.
- W2121819563 hasRelatedWork W2072933097 @default.
- W2121819563 hasRelatedWork W2086974024 @default.
- W2121819563 hasRelatedWork W2113445723 @default.
- W2121819563 hasRelatedWork W2138029698 @default.
- W2121819563 hasRelatedWork W2215173717 @default.
- W2121819563 hasRelatedWork W2529319165 @default.
- W2121819563 hasRelatedWork W926273471 @default.
- W2121819563 hasRelatedWork W980355759 @default.
- W2121819563 hasRelatedWork W1998704961 @default.
- W2121819563 hasRelatedWork W95326025 @default.
- W2121819563 isParatext "false" @default.
- W2121819563 isRetracted "false" @default.
- W2121819563 magId "2121819563" @default.
- W2121819563 workType "article" @default.