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• W2121837384 endingPage "n/a" @default.
• W2121837384 startingPage "n/a" @default.
• W2121837384 abstract "Neural tube defects (NTDs) are the second most common birth defects in the United States. It is well known that folic acid supplementation decreases about 70% of all NTDs, although the mechanism by which this occurs is still relatively unknown. The current theory is that folic acid deficiency ultimately leads to depletion of the methyl pool, leaving critical genes unmethylated, and, in turn, their improper expression leads to failure of normal neural tube development. Recently, new studies in human cell lines have shown that folic acid deficiency and DNA hypomethylation can lead to misexpression of microRNAs (miRNAs). Misexpression of critical miRNAs during neural development may lead to a subtle effect on neural gene regulation, causing the sometimes mild to severely debilitating range of phenotypes exhibited in NTDs. This review seeks to cohesively integrate current information regarding folic acid deficiency, methylation cycles, neural development, and miRNAs to propose a potential model of NTD formation. In addition, we have examined the relevant gene pathways and miRNAs that are predicted to affect them, and based on our investigation, we have devised a basic template of experiments for exploring the idea that miRNA misregulation may be linked to folic acid deficiency and NTDs. genesis 48:282–294, 2010. © 2010 Wiley-Liss, Inc." @default.
• W2121837384 created "2016-06-24" @default.
• W2121837384 creator A5061997342 @default.
• W2121837384 creator A5083808447 @default.
• W2121837384 date "2010-03-12" @default.
• W2121837384 modified "2023-10-01" @default.
• W2121837384 title "A new perspective on neural tube defects: Folic acid and microRNA misexpression" @default.
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• W2121837384 doi "https://doi.org/10.1002/dvg.20623" @default.
• W2121837384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20229516" @default.
• W2121837384 hasPublicationYear "2010" @default.
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