FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121838863> ?p ?o ?g. }

• W2121838863 endingPage "149" @default.
• W2121838863 startingPage "142" @default.
• W2121838863 abstract "Despite the popularity of 3T3-L1 adipocytes as a model system of adipocytes in vivo, they do not carry all of the cellular functions of adipocytes in vivo. In this study, we investigated the effect of extracellular matrix (ECM) rigidity on insulin signal transduction in 3T3-L1 adipocytes. On 250 Pa polyacrylamide gel (soft gel) laminated with a mixture of collagen type 1 and fibronectin, whose rigidity matches that of adipose tissue, expression of the insulin receptor, IRS-1 and AKT was upregulated and their insulin-stimulated phosphorylation was enhanced. Furthermore, the expression of GLUT1 was downregulated, whereas the expression of GLUT4 was unaffected as ECM rigidity decreased. Insulin-stimulated GLUT4 recruitment to the plasma membrane was significantly enhanced in cells seeded on soft gel. These results suggest that adjusting the ECM rigidity to that of adipose tissue augments insulin signaling in 3T3-L1 adipocytes and enhances insulin-stimulated GLUT4 recruitment to the plasma membrane. J. Med. Invest. 56: 142-149, August, 2009" @default.
• W2121838863 created "2016-06-24" @default.
• W2121838863 creator A5038923350 @default.
• W2121838863 creator A5060949390 @default.
• W2121838863 creator A5066087614 @default.
• W2121838863 creator A5078703658 @default.
• W2121838863 creator A5080905237 @default.
• W2121838863 date "2009-01-01" @default.
• W2121838863 modified "2023-09-23" @default.
• W2121838863 title "Extracellular matrix with the rigidity of adipose tissue helps 3T3-L1 adipocytes maintain insulin responsiveness" @default.
• W2121838863 cites W1525431775 @default.
• W2121838863 cites W1564626456 @default.
• W2121838863 cites W1973089587 @default.
• W2121838863 cites W1981594750 @default.
• W2121838863 cites W1982130586 @default.
• W2121838863 cites W1998287390 @default.
• W2121838863 cites W2009181620 @default.
• W2121838863 cites W2021168605 @default.
• W2121838863 cites W2031450490 @default.
• W2121838863 cites W2045984022 @default.
• W2121838863 cites W2071692398 @default.
• W2121838863 cites W2095301611 @default.
• W2121838863 cites W2101904950 @default.
• W2121838863 cites W2118130192 @default.
• W2121838863 cites W2125509960 @default.
• W2121838863 cites W2125756645 @default.
• W2121838863 cites W2134208433 @default.
• W2121838863 cites W2148328620 @default.
• W2121838863 cites W2156589968 @default.
• W2121838863 cites W2167243609 @default.
• W2121838863 cites W2171244349 @default.
• W2121838863 doi "https://doi.org/10.2152/jmi.56.142" @default.
• W2121838863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19763027" @default.
• W2121838863 hasPublicationYear "2009" @default.
• W2121838863 type Work @default.
• W2121838863 sameAs 2121838863 @default.
• W2121838863 citedByCount "18" @default.
• W2121838863 countsByYear W21218388632012 @default.
• W2121838863 countsByYear W21218388632013 @default.
• W2121838863 countsByYear W21218388632014 @default.
• W2121838863 countsByYear W21218388632015 @default.
• W2121838863 countsByYear W21218388632016 @default.
• W2121838863 countsByYear W21218388632018 @default.
• W2121838863 countsByYear W21218388632020 @default.
• W2121838863 countsByYear W21218388632021 @default.
• W2121838863 countsByYear W21218388632022 @default.
• W2121838863 crossrefType "journal-article" @default.
• W2121838863 hasAuthorship W2121838863A5038923350 @default.
• W2121838863 hasAuthorship W2121838863A5060949390 @default.
• W2121838863 hasAuthorship W2121838863A5066087614 @default.
• W2121838863 hasAuthorship W2121838863A5078703658 @default.
• W2121838863 hasAuthorship W2121838863A5080905237 @default.
• W2121838863 hasBestOaLocation W21218388631 @default.
• W2121838863 hasConcept C104317684 @default.
• W2121838863 hasConcept C112446052 @default.
• W2121838863 hasConcept C122927707 @default.
• W2121838863 hasConcept C126322002 @default.
• W2121838863 hasConcept C127561419 @default.
• W2121838863 hasConcept C134018914 @default.
• W2121838863 hasConcept C142536801 @default.
• W2121838863 hasConcept C171089720 @default.
• W2121838863 hasConcept C185592680 @default.
• W2121838863 hasConcept C189165786 @default.
• W2121838863 hasConcept C2776188179 @default.
• W2121838863 hasConcept C2777391703 @default.
• W2121838863 hasConcept C2777866211 @default.
• W2121838863 hasConcept C2777952866 @default.
• W2121838863 hasConcept C2779306644 @default.
• W2121838863 hasConcept C55493867 @default.
• W2121838863 hasConcept C71924100 @default.
• W2121838863 hasConcept C86492073 @default.
• W2121838863 hasConcept C86803240 @default.
• W2121838863 hasConcept C95444343 @default.
• W2121838863 hasConceptScore W2121838863C104317684 @default.
• W2121838863 hasConceptScore W2121838863C112446052 @default.
• W2121838863 hasConceptScore W2121838863C122927707 @default.
• W2121838863 hasConceptScore W2121838863C126322002 @default.
• W2121838863 hasConceptScore W2121838863C127561419 @default.
• W2121838863 hasConceptScore W2121838863C134018914 @default.
• W2121838863 hasConceptScore W2121838863C142536801 @default.
• W2121838863 hasConceptScore W2121838863C171089720 @default.
• W2121838863 hasConceptScore W2121838863C185592680 @default.
• W2121838863 hasConceptScore W2121838863C189165786 @default.
• W2121838863 hasConceptScore W2121838863C2776188179 @default.
• W2121838863 hasConceptScore W2121838863C2777391703 @default.
• W2121838863 hasConceptScore W2121838863C2777866211 @default.
• W2121838863 hasConceptScore W2121838863C2777952866 @default.
• W2121838863 hasConceptScore W2121838863C2779306644 @default.
• W2121838863 hasConceptScore W2121838863C55493867 @default.
• W2121838863 hasConceptScore W2121838863C71924100 @default.
• W2121838863 hasConceptScore W2121838863C86492073 @default.
• W2121838863 hasConceptScore W2121838863C86803240 @default.
• W2121838863 hasConceptScore W2121838863C95444343 @default.
• W2121838863 hasIssue "3,4" @default.
• W2121838863 hasLocation W21218388631 @default.
• W2121838863 hasLocation W21218388632 @default.
• W2121838863 hasOpenAccess W2121838863 @default.
• W2121838863 hasPrimaryLocation W21218388631 @default.

• next