FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121842015> ?p ?o ?g. }

• W2121842015 endingPage "E116" @default.
• W2121842015 startingPage "E110" @default.
• W2121842015 abstract "Renin-angiotensin-aldosterone system (RAAS) activation mediates increases in reactive oxygen species (ROS) and impaired insulin signaling. The transgenic Ren2 rat manifests increased tissue renin-angiotensin system activity, elevated serum aldosterone, hypertension, and insulin resistance. To explore the role of aldosterone in the pathogenesis of insulin resistance, we investigated the impact of in vivo treatment with a mineralocorticoid receptor (MR) antagonist on insulin sensitivity in Ren2 and aged-matched Sprague-Dawley (SD) control rats. Both groups (age 6–8 wk) were implanted with subcutaneous time-release pellets containing spironolactone (0.24 mg/day) or placebo over 21 days. Systolic blood pressure (SBP) and intraperitoneal glucose tolerance test were determined. Soleus muscle insulin receptor substrate-1 (IRS-1), tyrosine phosphorylated IRS-1, protein kinase B (Akt) phosphorylation, GLUT4 levels, and insulin-stimulated 2-deoxyglucose uptake were evaluated in relation to NADPH subunit expression/oxidase activity and ROS production (chemiluminescence and 4-hydroxy-2-nonenal immunostaining). Along with increased soleus muscle NADPH oxidase activity and ROS, there was systemic insulin resistance and reduced muscle IRS-1 tyrosine phosphorylation, Akt phosphorylation/activation, and GLUT4 expression in the Ren2 group (each P < 0.05). Despite not decreasing blood pressure, low-dose spironolactone treatment improved soleus muscle insulin signaling parameters and systemic insulin sensitivity in concert with reductions in NADPH oxidase subunit expression/activity and ROS production (each P < 0.05). Our findings suggest that aldosterone contributes to insulin resistance in the transgenic Ren2, in part, by increasing NADPH oxidase activity in skeletal muscle tissue." @default.
• W2121842015 created "2016-06-24" @default.
• W2121842015 creator A5001968810 @default.
• W2121842015 creator A5006212343 @default.
• W2121842015 creator A5013737413 @default.
• W2121842015 creator A5019241798 @default.
• W2121842015 creator A5023010276 @default.
• W2121842015 creator A5056018448 @default.
• W2121842015 creator A5058451510 @default.
• W2121842015 creator A5082502495 @default.
• W2121842015 creator A5084918480 @default.
• W2121842015 creator A5088391372 @default.
• W2121842015 date "2008-07-01" @default.
• W2121842015 modified "2023-09-24" @default.
• W2121842015 title "Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat" @default.
• W2121842015 cites W1558440797 @default.
• W2121842015 cites W1966198968 @default.
• W2121842015 cites W2004674731 @default.
• W2121842015 cites W2011683519 @default.
• W2121842015 cites W2013599521 @default.
• W2121842015 cites W2022275442 @default.
• W2121842015 cites W2041001158 @default.
• W2121842015 cites W2051150435 @default.
• W2121842015 cites W2051678468 @default.
• W2121842015 cites W2076347631 @default.
• W2121842015 cites W2084699108 @default.
• W2121842015 cites W2087742925 @default.
• W2121842015 cites W2091272291 @default.
• W2121842015 cites W2099583783 @default.
• W2121842015 cites W2102683312 @default.
• W2121842015 cites W2104954391 @default.
• W2121842015 cites W2107418117 @default.
• W2121842015 cites W2112748083 @default.
• W2121842015 cites W2114856643 @default.
• W2121842015 cites W2117663124 @default.
• W2121842015 cites W2119783613 @default.
• W2121842015 cites W2124037655 @default.
• W2121842015 cites W2133381439 @default.
• W2121842015 cites W2134498505 @default.
• W2121842015 cites W2135788465 @default.
• W2121842015 cites W2136352347 @default.
• W2121842015 cites W2142670938 @default.
• W2121842015 cites W2143722118 @default.
• W2121842015 cites W2151139437 @default.
• W2121842015 cites W2152094259 @default.
• W2121842015 cites W2154015803 @default.
• W2121842015 cites W2156783035 @default.
• W2121842015 cites W2159785173 @default.
• W2121842015 cites W2170605369 @default.
• W2121842015 cites W2323458614 @default.
• W2121842015 cites W2414374609 @default.
• W2121842015 cites W4256719287 @default.
• W2121842015 doi "https://doi.org/10.1152/ajpendo.00258.2007" @default.
• W2121842015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2493595" @default.
• W2121842015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18445755" @default.
• W2121842015 hasPublicationYear "2008" @default.
• W2121842015 type Work @default.
• W2121842015 sameAs 2121842015 @default.
• W2121842015 citedByCount "97" @default.
• W2121842015 countsByYear W21218420152012 @default.
• W2121842015 countsByYear W21218420152013 @default.
• W2121842015 countsByYear W21218420152014 @default.
• W2121842015 countsByYear W21218420152015 @default.
• W2121842015 countsByYear W21218420152016 @default.
• W2121842015 countsByYear W21218420152017 @default.
• W2121842015 countsByYear W21218420152018 @default.
• W2121842015 countsByYear W21218420152019 @default.
• W2121842015 countsByYear W21218420152020 @default.
• W2121842015 countsByYear W21218420152021 @default.
• W2121842015 countsByYear W21218420152022 @default.
• W2121842015 countsByYear W21218420152023 @default.
• W2121842015 crossrefType "journal-article" @default.
• W2121842015 hasAuthorship W2121842015A5001968810 @default.
• W2121842015 hasAuthorship W2121842015A5006212343 @default.
• W2121842015 hasAuthorship W2121842015A5013737413 @default.
• W2121842015 hasAuthorship W2121842015A5019241798 @default.
• W2121842015 hasAuthorship W2121842015A5023010276 @default.
• W2121842015 hasAuthorship W2121842015A5056018448 @default.
• W2121842015 hasAuthorship W2121842015A5058451510 @default.
• W2121842015 hasAuthorship W2121842015A5082502495 @default.
• W2121842015 hasAuthorship W2121842015A5084918480 @default.
• W2121842015 hasAuthorship W2121842015A5088391372 @default.
• W2121842015 hasBestOaLocation W21218420152 @default.
• W2121842015 hasConcept C112446052 @default.
• W2121842015 hasConcept C126322002 @default.
• W2121842015 hasConcept C134018914 @default.
• W2121842015 hasConcept C185592680 @default.
• W2121842015 hasConcept C2776151105 @default.
• W2121842015 hasConcept C2776188179 @default.
• W2121842015 hasConcept C2777391703 @default.
• W2121842015 hasConcept C2778525890 @default.
• W2121842015 hasConcept C2779306644 @default.
• W2121842015 hasConcept C2779719074 @default.
• W2121842015 hasConcept C71924100 @default.
• W2121842015 hasConcept C86803240 @default.
• W2121842015 hasConceptScore W2121842015C112446052 @default.
• W2121842015 hasConceptScore W2121842015C126322002 @default.
• W2121842015 hasConceptScore W2121842015C134018914 @default.

• next