Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121851876> ?p ?o ?g. }
- W2121851876 endingPage "7860" @default.
- W2121851876 startingPage "7850" @default.
- W2121851876 abstract "Gene expression profile was analyzed in 68 stage I and 15 borderline ovarian cancers to determine if different clinical features of stage I ovarian cancer such as histotype, grade, and survival are related to differential gene expression.Tumors were obtained directly at surgery and immediately frozen in liquid nitrogen until analysis. Glass arrays containing 16,000 genes were used in a dual-color assay labeling protocol.Unsupervised analysis identified eight major patient partitions, one of which was statistically associated to overall survival, grading, and histotype and another with grading and histotype. Supervised analysis allowed detection of gene profiles clearly associated to histotype or to degree of differentiation. No difference was found between borderline and grade 1 tumors. As to recurrence, a subset of genes able to differentiate relapsers from nonrelapsers was identified. Among these, cyclin E and minichromosome maintenance protein 5 were found particularly relevant, as their expression was inversely correlated to progression-free survival (P = 0.00033 and 0.017, respectively).Specific molecular signatures define different histotypes and prognosis of stage I ovarian cancer. Mucinous and clear cells histotypes can be distinguished from the others regardless of tumor grade. Cyclin E and minichromosome maintenance protein 5, whose expression was found previously to be related to a bad prognosis of advanced ovarian cancer, appear to be potential prognostic markers in stage I ovarian cancer too, independent of other pathologic and clinical variables." @default.
- W2121851876 created "2016-06-24" @default.
- W2121851876 creator A5003180276 @default.
- W2121851876 creator A5005760108 @default.
- W2121851876 creator A5010972450 @default.
- W2121851876 creator A5018539503 @default.
- W2121851876 creator A5025190469 @default.
- W2121851876 creator A5035793612 @default.
- W2121851876 creator A5045396654 @default.
- W2121851876 creator A5048173478 @default.
- W2121851876 creator A5052679679 @default.
- W2121851876 creator A5055703421 @default.
- W2121851876 creator A5065205592 @default.
- W2121851876 creator A5065551274 @default.
- W2121851876 creator A5069986334 @default.
- W2121851876 creator A5091714925 @default.
- W2121851876 date "2008-12-01" @default.
- W2121851876 modified "2023-10-18" @default.
- W2121851876 title "Analysis of Gene Expression in Early-Stage Ovarian Cancer" @default.
- W2121851876 cites W1966701961 @default.
- W2121851876 cites W1966969455 @default.
- W2121851876 cites W1969264492 @default.
- W2121851876 cites W1970401205 @default.
- W2121851876 cites W1977195128 @default.
- W2121851876 cites W1977354546 @default.
- W2121851876 cites W1984004506 @default.
- W2121851876 cites W1987572677 @default.
- W2121851876 cites W1996465736 @default.
- W2121851876 cites W1998258610 @default.
- W2121851876 cites W2004575269 @default.
- W2121851876 cites W2010317565 @default.
- W2121851876 cites W2013246256 @default.
- W2121851876 cites W2013528590 @default.
- W2121851876 cites W2013764640 @default.
- W2121851876 cites W2013896443 @default.
- W2121851876 cites W2026379833 @default.
- W2121851876 cites W2036242721 @default.
- W2121851876 cites W2036292252 @default.
- W2121851876 cites W2038390682 @default.
- W2121851876 cites W2038849147 @default.
- W2121851876 cites W2039634280 @default.
- W2121851876 cites W2040615655 @default.
- W2121851876 cites W2043235003 @default.
- W2121851876 cites W2043754674 @default.
- W2121851876 cites W2044153456 @default.
- W2121851876 cites W2091531676 @default.
- W2121851876 cites W2092022173 @default.
- W2121851876 cites W2101185543 @default.
- W2121851876 cites W2102330962 @default.
- W2121851876 cites W2115596977 @default.
- W2121851876 cites W2116815663 @default.
- W2121851876 cites W2122058957 @default.
- W2121851876 cites W2130202432 @default.
- W2121851876 cites W2132261436 @default.
- W2121851876 cites W2135844005 @default.
- W2121851876 cites W2138550913 @default.
- W2121851876 cites W2144737008 @default.
- W2121851876 cites W2158227917 @default.
- W2121851876 cites W2161978587 @default.
- W2121851876 cites W2166500526 @default.
- W2121851876 cites W3143026348 @default.
- W2121851876 cites W4243210578 @default.
- W2121851876 cites W4294107304 @default.
- W2121851876 doi "https://doi.org/10.1158/1078-0432.ccr-08-0523" @default.
- W2121851876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19047114" @default.
- W2121851876 hasPublicationYear "2008" @default.
- W2121851876 type Work @default.
- W2121851876 sameAs 2121851876 @default.
- W2121851876 citedByCount "36" @default.
- W2121851876 countsByYear W21218518762012 @default.
- W2121851876 countsByYear W21218518762013 @default.
- W2121851876 countsByYear W21218518762014 @default.
- W2121851876 countsByYear W21218518762015 @default.
- W2121851876 countsByYear W21218518762016 @default.
- W2121851876 countsByYear W21218518762017 @default.
- W2121851876 countsByYear W21218518762018 @default.
- W2121851876 countsByYear W21218518762021 @default.
- W2121851876 countsByYear W21218518762022 @default.
- W2121851876 crossrefType "journal-article" @default.
- W2121851876 hasAuthorship W2121851876A5003180276 @default.
- W2121851876 hasAuthorship W2121851876A5005760108 @default.
- W2121851876 hasAuthorship W2121851876A5010972450 @default.
- W2121851876 hasAuthorship W2121851876A5018539503 @default.
- W2121851876 hasAuthorship W2121851876A5025190469 @default.
- W2121851876 hasAuthorship W2121851876A5035793612 @default.
- W2121851876 hasAuthorship W2121851876A5045396654 @default.
- W2121851876 hasAuthorship W2121851876A5048173478 @default.
- W2121851876 hasAuthorship W2121851876A5052679679 @default.
- W2121851876 hasAuthorship W2121851876A5055703421 @default.
- W2121851876 hasAuthorship W2121851876A5065205592 @default.
- W2121851876 hasAuthorship W2121851876A5065551274 @default.
- W2121851876 hasAuthorship W2121851876A5069986334 @default.
- W2121851876 hasAuthorship W2121851876A5091714925 @default.
- W2121851876 hasBestOaLocation W21218518762 @default.
- W2121851876 hasConcept C104317684 @default.
- W2121851876 hasConcept C121608353 @default.
- W2121851876 hasConcept C142724271 @default.
- W2121851876 hasConcept C143998085 @default.