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- W2121857683 abstract "BackgroundDevelopmental exposure to a wide variety of developmental neurotoxicants, including organophosphate pesticides, evokes late-emerging and persistent abnormalities in acetylcholine (ACh) systems. We are seeking interventions that can ameliorate or reverse the effects later in life.ObjectivesWe administered parathion to neonatal rats and then evaluated whether a high-fat diet begun in adulthood could reverse the effects on ACh systems.MethodsNeonatal rats received parathion on postnatal days 1–4 at 0.1 or 0.2 mg/kg/day, straddling the cholinesterase inhibition threshold. In adulthood, half the animals were switched to a high-fat diet for 8 weeks. We assessed three indices of ACh synaptic function: nicotinic ACh receptor binding, choline acetyltransferase activity, and hemicholinium-3 binding. Determinations were performed in brain regions comprising all the major ACh projections and cell bodies.ResultsNeonatal parathion exposure evoked widespread abnormalities in ACh synaptic markers, encompassing effects in brain regions possessing ACh projections and ACh cell bodies. In general, males were affected more than females. Of 17 regional ACh marker abnormalities (10 male, 7 female), 15 were reversed by the high-fat diet.ConclusionsA high-fat diet reverses neurodevelopmental effects of neonatal parathion exposure on ACh systems. This points to the potential for nonpharmacologic interventions to offset the effects of developmental neurotoxicants. Further, cryptic neurodevelopmental deficits evoked by environmental exposures may thus engender a later preference for a high-fat diet to maintain normal ACh function, ultimately contributing to obesity." @default.
- W2121857683 created "2016-06-24" @default.
- W2121857683 creator A5000464378 @default.
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- W2121857683 creator A5034856835 @default.
- W2121857683 creator A5038298482 @default.
- W2121857683 date "2009-06-01" @default.
- W2121857683 modified "2023-10-18" @default.
- W2121857683 title "Consumption of a High-Fat Diet in Adulthood Ameliorates the Effects of Neonatal Parathion Exposure on Acetylcholine Systems in Rat Brain Regions" @default.
- W2121857683 cites W109869948 @default.
- W2121857683 cites W1538978850 @default.
- W2121857683 cites W1564190433 @default.
- W2121857683 cites W1884123732 @default.
- W2121857683 cites W1966527651 @default.
- W2121857683 cites W1966556786 @default.
- W2121857683 cites W1966811160 @default.
- W2121857683 cites W1971051930 @default.
- W2121857683 cites W1971354169 @default.
- W2121857683 cites W1974791181 @default.
- W2121857683 cites W1976161943 @default.
- W2121857683 cites W1976298317 @default.
- W2121857683 cites W1977293819 @default.
- W2121857683 cites W1980641807 @default.
- W2121857683 cites W1984317805 @default.
- W2121857683 cites W1984447821 @default.
- W2121857683 cites W1989414037 @default.
- W2121857683 cites W1989689679 @default.
- W2121857683 cites W1992853156 @default.
- W2121857683 cites W1993689412 @default.
- W2121857683 cites W1993737224 @default.
- W2121857683 cites W1995506768 @default.
- W2121857683 cites W1996111288 @default.
- W2121857683 cites W2002806814 @default.
- W2121857683 cites W2006829255 @default.
- W2121857683 cites W2008346372 @default.
- W2121857683 cites W2009131129 @default.
- W2121857683 cites W2011735194 @default.
- W2121857683 cites W2012001266 @default.
- W2121857683 cites W2012471271 @default.
- W2121857683 cites W2014216862 @default.
- W2121857683 cites W2021807237 @default.
- W2121857683 cites W2022598221 @default.
- W2121857683 cites W2025122498 @default.
- W2121857683 cites W2025778428 @default.
- W2121857683 cites W2026284079 @default.
- W2121857683 cites W2028098691 @default.
- W2121857683 cites W2029483298 @default.
- W2121857683 cites W2030842083 @default.
- W2121857683 cites W2030907867 @default.
- W2121857683 cites W2035854332 @default.
- W2121857683 cites W2038450393 @default.
- W2121857683 cites W2042529247 @default.
- W2121857683 cites W2044459149 @default.
- W2121857683 cites W2045725740 @default.
- W2121857683 cites W2047021275 @default.
- W2121857683 cites W2048269119 @default.
- W2121857683 cites W2048637344 @default.
- W2121857683 cites W2049875250 @default.
- W2121857683 cites W2050046362 @default.
- W2121857683 cites W2050458386 @default.
- W2121857683 cites W2051681662 @default.
- W2121857683 cites W2052893224 @default.
- W2121857683 cites W2053946491 @default.
- W2121857683 cites W2055844265 @default.
- W2121857683 cites W2055972657 @default.
- W2121857683 cites W2057455742 @default.
- W2121857683 cites W2059568934 @default.
- W2121857683 cites W2061362312 @default.
- W2121857683 cites W2061475648 @default.
- W2121857683 cites W2061562298 @default.
- W2121857683 cites W2063324541 @default.
- W2121857683 cites W2063890226 @default.
- W2121857683 cites W2065871313 @default.
- W2121857683 cites W2067715785 @default.
- W2121857683 cites W2068145071 @default.
- W2121857683 cites W2068432022 @default.
- W2121857683 cites W2073007291 @default.
- W2121857683 cites W2078181188 @default.
- W2121857683 cites W2079581846 @default.
- W2121857683 cites W2085423497 @default.
- W2121857683 cites W2090701150 @default.
- W2121857683 cites W2091027958 @default.
- W2121857683 cites W2092961001 @default.
- W2121857683 cites W2106130355 @default.
- W2121857683 cites W2108779378 @default.
- W2121857683 cites W2109812130 @default.
- W2121857683 cites W2113103898 @default.
- W2121857683 cites W2132960246 @default.
- W2121857683 cites W2136763318 @default.
- W2121857683 cites W2139214499 @default.
- W2121857683 cites W2142644111 @default.
- W2121857683 cites W2143029457 @default.
- W2121857683 cites W2143665761 @default.
- W2121857683 cites W2144961968 @default.
- W2121857683 cites W2153609942 @default.
- W2121857683 cites W2163837911 @default.