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• W2121891764 abstract "During G2 phase of cell cycle, centrosomes function as a scaffold for activation of mitotic kinases. Aurora-A is first activated at late G2 phase at the centrosome, facilitates centrosome maturation, and induces activation of cyclin B-Cdk1 at the centrosome for mitotic entry. Although several molecules including HEF1 and PAK are implicated in centrosomal activation of Aurora-A, signaling pathways leading to Aurora-A activation at the centrosome, and hence mitotic commitment in vertebrate cells remains largely unknown. Here, we have used Clostridium difficile toxin B and examined the role of Rho GTPases in G2/M transition of HeLa cells. Inactivation of Rho GTPases by the toxin B treatment delayed by 2 h histone H3 phosphorylation, Cdk1/cyclin B activation, and Aurora-A activation. Furthermore, PAK activation at the centrosome that was already present before the toxin addition was significantly attenuated for 2 h by the addition of toxin B, and HEF1 accumulation at the centrosome that occurred in late G2 phase was also delayed. These results suggest that Rho GTPases function in G2/M transition of mammalian cells by mediating multiple signaling pathways converging to centrosomal activation of Aurora-A." @default.
• W2121891764 created "2016-06-24" @default.
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• W2121891764 creator A5061248029 @default.
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• W2121891764 date "2007-10-01" @default.
• W2121891764 modified "2023-09-25" @default.
• W2121891764 title "Inactivation of Rho GTPases with<i>Clostridium difficile</i>Toxin B Impairs Centrosomal Activation of Aurora-A in G2/M Transition of HeLa Cells" @default.
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• W2121891764 doi "https://doi.org/10.1091/mbc.e07-03-0281" @default.
• W2121891764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995717" @default.
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