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- W2121892287 abstract "High-intensity focused-ultrasound (HIFU) has been successfully employed for thermal ablation of tumors in clinical settings. Continuous- or pulsed-mode HIFU may also induce a host antitumor immune response, mainly through expansion of antigen-presenting cells in response to increased cellular debris and through increased macrophage activation/infiltration. Here we demonstrated that another form of focused ultrasound delivery, using low-pressure, pulsed-mode exposure in the presence of microbubbles (MBs), may also trigger an antitumor immunological response and inhibit tumor growth.A total of 280 tumor-bearing animals were subjected to sonographically-guided FUS. Implanted tumors were exposed to low-pressure FUS (0.6 to 1.4 MPa) with MBs to increase the permeability of tumor microvasculature.Tumor progression was suppressed by both 0.6 and 1.4-MPa MB-enhanced FUS exposures. We observed a transient increase in infiltration of non-T regulatory (non-Treg) tumor infiltrating lymphocytes (TILs) and continual infiltration of CD8+ cytotoxic T-lymphocytes (CTL). The ratio of CD8+/Treg increased significantly and tumor growth was inhibited.Our findings suggest that low-pressure FUS exposure with MBs may constitute a useful tool for triggering an anticancer immune response, for potential cancer immunotherapy." @default.
- W2121892287 created "2016-06-24" @default.
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- W2121892287 date "2012-11-11" @default.
- W2121892287 modified "2023-10-16" @default.
- W2121892287 title "Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response" @default.
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- W2121892287 doi "https://doi.org/10.1186/1479-5876-10-221" @default.
- W2121892287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3543346" @default.
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