Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121894911> ?p ?o ?g. }
- W2121894911 endingPage "2704" @default.
- W2121894911 startingPage "2699" @default.
- W2121894911 abstract "Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate in vitro that acetaminophen inhibits hemoprotein-induced lipid peroxidation by reducing ferryl heme to its ferric state and quenching globin radicals. Severe muscle injury (rhabdomyolysis) is accompanied by the release of myoglobin that becomes deposited in the kidney, causing renal injury. We previously showed in a rat model of rhabdomyolysis that redox cycling between ferric and ferryl myoglobin yields radical species that cause severe oxidative damage to the kidney. In this model, acetaminophen at therapeutic plasma concentrations significantly decreased oxidant injury in the kidney, improved renal function, and reduced renal damage. These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury." @default.
- W2121894911 created "2016-06-24" @default.
- W2121894911 creator A5004412855 @default.
- W2121894911 creator A5026806093 @default.
- W2121894911 creator A5029767434 @default.
- W2121894911 creator A5038693687 @default.
- W2121894911 creator A5052435494 @default.
- W2121894911 creator A5058241857 @default.
- W2121894911 creator A5059857190 @default.
- W2121894911 creator A5060339946 @default.
- W2121894911 creator A5063917515 @default.
- W2121894911 creator A5071394614 @default.
- W2121894911 creator A5075984448 @default.
- W2121894911 creator A5082915732 @default.
- W2121894911 creator A5088306377 @default.
- W2121894911 date "2010-02-01" @default.
- W2121894911 modified "2023-10-02" @default.
- W2121894911 title "Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure" @default.
- W2121894911 cites W1575468184 @default.
- W2121894911 cites W1604766895 @default.
- W2121894911 cites W1605371693 @default.
- W2121894911 cites W1878772812 @default.
- W2121894911 cites W1915459106 @default.
- W2121894911 cites W1965153009 @default.
- W2121894911 cites W1965860794 @default.
- W2121894911 cites W1993962505 @default.
- W2121894911 cites W1995879725 @default.
- W2121894911 cites W1996461361 @default.
- W2121894911 cites W1998049068 @default.
- W2121894911 cites W2003972389 @default.
- W2121894911 cites W2006767862 @default.
- W2121894911 cites W2008566131 @default.
- W2121894911 cites W2009814003 @default.
- W2121894911 cites W2027253279 @default.
- W2121894911 cites W2032414987 @default.
- W2121894911 cites W2041368041 @default.
- W2121894911 cites W2042725396 @default.
- W2121894911 cites W2042895175 @default.
- W2121894911 cites W2046269757 @default.
- W2121894911 cites W2047320077 @default.
- W2121894911 cites W2050739900 @default.
- W2121894911 cites W2053857502 @default.
- W2121894911 cites W2060917322 @default.
- W2121894911 cites W2061297953 @default.
- W2121894911 cites W2066033241 @default.
- W2121894911 cites W2066806328 @default.
- W2121894911 cites W2067264904 @default.
- W2121894911 cites W2068513248 @default.
- W2121894911 cites W2074668577 @default.
- W2121894911 cites W2075183124 @default.
- W2121894911 cites W2078601157 @default.
- W2121894911 cites W2099534133 @default.
- W2121894911 cites W2103574978 @default.
- W2121894911 cites W2103634916 @default.
- W2121894911 cites W2115485369 @default.
- W2121894911 cites W2143091695 @default.
- W2121894911 cites W2150449873 @default.
- W2121894911 cites W2167516074 @default.
- W2121894911 cites W2246286030 @default.
- W2121894911 cites W2326132095 @default.
- W2121894911 cites W2333982488 @default.
- W2121894911 cites W2417842233 @default.
- W2121894911 cites W2470393658 @default.
- W2121894911 doi "https://doi.org/10.1073/pnas.0910174107" @default.
- W2121894911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2823910" @default.
- W2121894911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20133658" @default.
- W2121894911 hasPublicationYear "2010" @default.
- W2121894911 type Work @default.
- W2121894911 sameAs 2121894911 @default.
- W2121894911 citedByCount "123" @default.
- W2121894911 countsByYear W21218949112012 @default.
- W2121894911 countsByYear W21218949112013 @default.
- W2121894911 countsByYear W21218949112014 @default.
- W2121894911 countsByYear W21218949112015 @default.
- W2121894911 countsByYear W21218949112016 @default.
- W2121894911 countsByYear W21218949112017 @default.
- W2121894911 countsByYear W21218949112018 @default.
- W2121894911 countsByYear W21218949112019 @default.
- W2121894911 countsByYear W21218949112020 @default.
- W2121894911 countsByYear W21218949112021 @default.
- W2121894911 countsByYear W21218949112022 @default.
- W2121894911 countsByYear W21218949112023 @default.
- W2121894911 crossrefType "journal-article" @default.
- W2121894911 hasAuthorship W2121894911A5004412855 @default.
- W2121894911 hasAuthorship W2121894911A5026806093 @default.
- W2121894911 hasAuthorship W2121894911A5029767434 @default.
- W2121894911 hasAuthorship W2121894911A5038693687 @default.
- W2121894911 hasAuthorship W2121894911A5052435494 @default.
- W2121894911 hasAuthorship W2121894911A5058241857 @default.
- W2121894911 hasAuthorship W2121894911A5059857190 @default.
- W2121894911 hasAuthorship W2121894911A5060339946 @default.
- W2121894911 hasAuthorship W2121894911A5063917515 @default.
- W2121894911 hasAuthorship W2121894911A5071394614 @default.
- W2121894911 hasAuthorship W2121894911A5075984448 @default.
- W2121894911 hasAuthorship W2121894911A5082915732 @default.
- W2121894911 hasAuthorship W2121894911A5088306377 @default.
- W2121894911 hasBestOaLocation W21218949112 @default.
- W2121894911 hasConcept C126322002 @default.