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• W2121904986 abstract "Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such cargo-motor motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes." @default.
• W2121904986 created "2016-06-24" @default.
• W2121904986 creator A5033475302 @default.
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• W2121904986 date "2012-07-12" @default.
• W2121904986 modified "2023-10-18" @default.
• W2121904986 title "Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport" @default.
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• W2121904986 doi "https://doi.org/10.1103/physrevlett.109.028104" @default.
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