FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121918633> ?p ?o ?g. }

• W2121918633 endingPage "982" @default.
• W2121918633 startingPage "972" @default.
• W2121918633 abstract "Background: In experimental settings, uranium is toxic to kidneys, but effects on humans are unclear. Ingestion of water from drilled wells is a source of high uranium exposure in some populations. Methods: Uranium exposure was measured in 95 men and 98 women aged 18 to 81 years who had used drinking water from drilled wells for an average of 16 years. Urinary N-acetyl-γ-d-glucosaminidase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyltransferase, and glutathione-S-transferase; serum cystatin C; and urinary and serum calcium, phosphate, glucose, and creatinine were measured to evaluate possible toxic effects of uranium on kidney cells and renal function. In addition, supine blood pressure was measured. Associations between uranium exposure and the outcome variables were modeled by using linear regression with adjustment for age, sex, body mass index, smoking, and analgesic use. Results: Median uranium concentration in drinking water was 25 μg/L (interquartile range, 5 to 148 μg/L; maximum, 1,500 μg/L). Indicators of cytotoxicity and kidney function did not show evidence of renal damage. No statistically significant associations with uranium in urine, water, hair, or toenails was found for 10 kidney toxicity indicators. Uranium exposure was associated with greater diastolic and systolic blood pressures, and cumulative uranium intake was associated with increased glucose excretion in urine. Conclusion: Continuous uranium intake from drinking water, even at relatively high exposures, was not found to have cytotoxic effects on kidneys in humans. Background: In experimental settings, uranium is toxic to kidneys, but effects on humans are unclear. Ingestion of water from drilled wells is a source of high uranium exposure in some populations. Methods: Uranium exposure was measured in 95 men and 98 women aged 18 to 81 years who had used drinking water from drilled wells for an average of 16 years. Urinary N-acetyl-γ-d-glucosaminidase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyltransferase, and glutathione-S-transferase; serum cystatin C; and urinary and serum calcium, phosphate, glucose, and creatinine were measured to evaluate possible toxic effects of uranium on kidney cells and renal function. In addition, supine blood pressure was measured. Associations between uranium exposure and the outcome variables were modeled by using linear regression with adjustment for age, sex, body mass index, smoking, and analgesic use. Results: Median uranium concentration in drinking water was 25 μg/L (interquartile range, 5 to 148 μg/L; maximum, 1,500 μg/L). Indicators of cytotoxicity and kidney function did not show evidence of renal damage. No statistically significant associations with uranium in urine, water, hair, or toenails was found for 10 kidney toxicity indicators. Uranium exposure was associated with greater diastolic and systolic blood pressures, and cumulative uranium intake was associated with increased glucose excretion in urine. Conclusion: Continuous uranium intake from drinking water, even at relatively high exposures, was not found to have cytotoxic effects on kidneys in humans." @default.
• W2121918633 created "2016-06-24" @default.
• W2121918633 creator A5002613773 @default.
• W2121918633 creator A5006105435 @default.
• W2121918633 creator A5029422912 @default.
• W2121918633 creator A5056092377 @default.
• W2121918633 creator A5058191124 @default.
• W2121918633 creator A5061742705 @default.
• W2121918633 creator A5075166539 @default.
• W2121918633 date "2006-06-01" @default.
• W2121918633 modified "2023-10-11" @default.
• W2121918633 title "Kidney Toxicity of Ingested Uranium From Drinking Water" @default.
• W2121918633 cites W144264313 @default.
• W2121918633 cites W1787560456 @default.
• W2121918633 cites W1902448003 @default.
• W2121918633 cites W1948821733 @default.
• W2121918633 cites W1964563773 @default.
• W2121918633 cites W1990007009 @default.
• W2121918633 cites W1995461705 @default.
• W2121918633 cites W2001908008 @default.
• W2121918633 cites W2006240659 @default.
• W2121918633 cites W2007163913 @default.
• W2121918633 cites W2028417151 @default.
• W2121918633 cites W2047242216 @default.
• W2121918633 cites W2061051981 @default.
• W2121918633 cites W206143243 @default.
• W2121918633 cites W2064677485 @default.
• W2121918633 cites W2065691944 @default.
• W2121918633 cites W2070630875 @default.
• W2121918633 cites W2075627504 @default.
• W2121918633 cites W2076765976 @default.
• W2121918633 cites W2082702063 @default.
• W2121918633 cites W2095437443 @default.
• W2121918633 cites W2115919451 @default.
• W2121918633 cites W2117733462 @default.
• W2121918633 cites W2118643584 @default.
• W2121918633 cites W2136077086 @default.
• W2121918633 cites W2139766106 @default.
• W2121918633 cites W2163831707 @default.
• W2121918633 cites W2165677439 @default.
• W2121918633 cites W2168438077 @default.
• W2121918633 cites W2898646414 @default.
• W2121918633 doi "https://doi.org/10.1053/j.ajkd.2006.03.002" @default.
• W2121918633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16731292" @default.
• W2121918633 hasPublicationYear "2006" @default.
• W2121918633 type Work @default.
• W2121918633 sameAs 2121918633 @default.
• W2121918633 citedByCount "166" @default.
• W2121918633 countsByYear W21219186332012 @default.
• W2121918633 countsByYear W21219186332013 @default.
• W2121918633 countsByYear W21219186332014 @default.
• W2121918633 countsByYear W21219186332015 @default.
• W2121918633 countsByYear W21219186332016 @default.
• W2121918633 countsByYear W21219186332017 @default.
• W2121918633 countsByYear W21219186332018 @default.
• W2121918633 countsByYear W21219186332019 @default.
• W2121918633 countsByYear W21219186332020 @default.
• W2121918633 countsByYear W21219186332021 @default.
• W2121918633 countsByYear W21219186332022 @default.
• W2121918633 countsByYear W21219186332023 @default.
• W2121918633 crossrefType "journal-article" @default.
• W2121918633 hasAuthorship W2121918633A5002613773 @default.
• W2121918633 hasAuthorship W2121918633A5006105435 @default.
• W2121918633 hasAuthorship W2121918633A5029422912 @default.
• W2121918633 hasAuthorship W2121918633A5056092377 @default.
• W2121918633 hasAuthorship W2121918633A5058191124 @default.
• W2121918633 hasAuthorship W2121918633A5061742705 @default.
• W2121918633 hasAuthorship W2121918633A5075166539 @default.
• W2121918633 hasConcept C126189478 @default.
• W2121918633 hasConcept C126322002 @default.
• W2121918633 hasConcept C134018914 @default.
• W2121918633 hasConcept C159641895 @default.
• W2121918633 hasConcept C191897082 @default.
• W2121918633 hasConcept C192562407 @default.
• W2121918633 hasConcept C193230392 @default.
• W2121918633 hasConcept C2780026642 @default.
• W2121918633 hasConcept C2780091579 @default.
• W2121918633 hasConcept C29730261 @default.
• W2121918633 hasConcept C33070731 @default.
• W2121918633 hasConcept C42407357 @default.
• W2121918633 hasConcept C555451288 @default.
• W2121918633 hasConcept C71924100 @default.
• W2121918633 hasConcept C86803240 @default.
• W2121918633 hasConceptScore W2121918633C126189478 @default.
• W2121918633 hasConceptScore W2121918633C126322002 @default.
• W2121918633 hasConceptScore W2121918633C134018914 @default.
• W2121918633 hasConceptScore W2121918633C159641895 @default.
• W2121918633 hasConceptScore W2121918633C191897082 @default.
• W2121918633 hasConceptScore W2121918633C192562407 @default.
• W2121918633 hasConceptScore W2121918633C193230392 @default.
• W2121918633 hasConceptScore W2121918633C2780026642 @default.
• W2121918633 hasConceptScore W2121918633C2780091579 @default.
• W2121918633 hasConceptScore W2121918633C29730261 @default.
• W2121918633 hasConceptScore W2121918633C33070731 @default.
• W2121918633 hasConceptScore W2121918633C42407357 @default.
• W2121918633 hasConceptScore W2121918633C555451288 @default.
• W2121918633 hasConceptScore W2121918633C71924100 @default.
• W2121918633 hasConceptScore W2121918633C86803240 @default.

• next