FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121922160> ?p ?o ?g. }

• W2121922160 endingPage "277" @default.
• W2121922160 startingPage "268" @default.
• W2121922160 abstract "Abstract Mannostatin A is a potent inhibitor of the mannose‐trimming enzyme, Golgi α‐mannosidase II (GMII), which acts late in the N ‐glycan processing pathway. Inhibition of this enzyme provides a route to blocking the transformation‐associated changes in cancer cell surface oligosaccharide structures. Here, we report on the synthesis of new Mannostatin derivatives and analyze their binding in the active site of Drosophila GMII by X‐ray crystallography. The results indicate that the interaction with the backbone carbonyl of Arg876 is crucial to the high potency of the inhibitor—an effect enhanced by the hydrophobic interaction between the thiomethyl group and an aromatic pocket vicinal to the cleavage site. The various structures indicate that differences in the hydration of protein–ligand complexes are also important determinants of plasticity as well as selectivity of inhibitor binding." @default.
• W2121922160 created "2016-06-24" @default.
• W2121922160 creator A5003905346 @default.
• W2121922160 creator A5006418968 @default.
• W2121922160 creator A5041094828 @default.
• W2121922160 creator A5074180325 @default.
• W2121922160 creator A5085497684 @default.
• W2121922160 date "2009-01-15" @default.
• W2121922160 modified "2023-10-18" @default.
• W2121922160 title "The Molecular Basis of Inhibition of Golgi α-Mannosidase II by Mannostatin A" @default.
• W2121922160 cites W1559526379 @default.
• W2121922160 cites W185660901 @default.
• W2121922160 cites W1965386926 @default.
• W2121922160 cites W1987137042 @default.
• W2121922160 cites W1992335263 @default.
• W2121922160 cites W1995017064 @default.
• W2121922160 cites W1997362085 @default.
• W2121922160 cites W1999722013 @default.
• W2121922160 cites W2012105936 @default.
• W2121922160 cites W2014548034 @default.
• W2121922160 cites W2017887262 @default.
• W2121922160 cites W2024720575 @default.
• W2121922160 cites W2025295232 @default.
• W2121922160 cites W2028383787 @default.
• W2121922160 cites W2033285121 @default.
• W2121922160 cites W2044034524 @default.
• W2121922160 cites W2056000901 @default.
• W2121922160 cites W2060248860 @default.
• W2121922160 cites W2060714229 @default.
• W2121922160 cites W2071349077 @default.
• W2121922160 cites W2086787941 @default.
• W2121922160 cites W2089483262 @default.
• W2121922160 cites W2095174264 @default.
• W2121922160 cites W2101609123 @default.
• W2121922160 cites W2102495530 @default.
• W2121922160 cites W2109202643 @default.
• W2121922160 cites W2115485185 @default.
• W2121922160 cites W2125289895 @default.
• W2121922160 cites W2128687047 @default.
• W2121922160 cites W2138891822 @default.
• W2121922160 cites W2144081223 @default.
• W2121922160 cites W2150730785 @default.
• W2121922160 cites W2164450010 @default.
• W2121922160 cites W2171045920 @default.
• W2121922160 cites W2172170166 @default.
• W2121922160 cites W2950390973 @default.
• W2121922160 doi "https://doi.org/10.1002/cbic.200800538" @default.
• W2121922160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3956299" @default.
• W2121922160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19101978" @default.
• W2121922160 hasPublicationYear "2009" @default.
• W2121922160 type Work @default.
• W2121922160 sameAs 2121922160 @default.
• W2121922160 citedByCount "36" @default.
• W2121922160 countsByYear W21219221602012 @default.
• W2121922160 countsByYear W21219221602013 @default.
• W2121922160 countsByYear W21219221602014 @default.
• W2121922160 countsByYear W21219221602015 @default.
• W2121922160 countsByYear W21219221602016 @default.
• W2121922160 countsByYear W21219221602017 @default.
• W2121922160 countsByYear W21219221602018 @default.
• W2121922160 countsByYear W21219221602019 @default.
• W2121922160 countsByYear W21219221602020 @default.
• W2121922160 countsByYear W21219221602021 @default.
• W2121922160 countsByYear W21219221602022 @default.
• W2121922160 crossrefType "journal-article" @default.
• W2121922160 hasAuthorship W2121922160A5003905346 @default.
• W2121922160 hasAuthorship W2121922160A5006418968 @default.
• W2121922160 hasAuthorship W2121922160A5041094828 @default.
• W2121922160 hasAuthorship W2121922160A5074180325 @default.
• W2121922160 hasAuthorship W2121922160A5085497684 @default.
• W2121922160 hasBestOaLocation W21219221602 @default.
• W2121922160 hasConcept C107824862 @default.
• W2121922160 hasConcept C108625454 @default.
• W2121922160 hasConcept C119062480 @default.
• W2121922160 hasConcept C1491633281 @default.
• W2121922160 hasConcept C151730666 @default.
• W2121922160 hasConcept C175156509 @default.
• W2121922160 hasConcept C181199279 @default.
• W2121922160 hasConcept C185592680 @default.
• W2121922160 hasConcept C206212055 @default.
• W2121922160 hasConcept C2775887612 @default.
• W2121922160 hasConcept C2777174400 @default.
• W2121922160 hasConcept C41183919 @default.
• W2121922160 hasConcept C43369102 @default.
• W2121922160 hasConcept C55493867 @default.
• W2121922160 hasConcept C71240020 @default.
• W2121922160 hasConcept C86803240 @default.
• W2121922160 hasConceptScore W2121922160C107824862 @default.
• W2121922160 hasConceptScore W2121922160C108625454 @default.
• W2121922160 hasConceptScore W2121922160C119062480 @default.
• W2121922160 hasConceptScore W2121922160C1491633281 @default.
• W2121922160 hasConceptScore W2121922160C151730666 @default.
• W2121922160 hasConceptScore W2121922160C175156509 @default.
• W2121922160 hasConceptScore W2121922160C181199279 @default.
• W2121922160 hasConceptScore W2121922160C185592680 @default.
• W2121922160 hasConceptScore W2121922160C206212055 @default.
• W2121922160 hasConceptScore W2121922160C2775887612 @default.
• W2121922160 hasConceptScore W2121922160C2777174400 @default.

• next