FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121932212> ?p ?o ?g. }

• W2121932212 endingPage "1810" @default.
• W2121932212 startingPage "1801" @default.
• W2121932212 abstract "The selective RNA-binding protein QKI is essential for myelination in the central nervous system (CNS). QKI belongs to the family of signal transduction activators of RNA (STARs), characteristic of binding RNA and signaling molecules, therefore is postulated to regulate RNA homeostasis in response to developmental signals. Here we report that QKI acts downstream of the Src family protein tyrosine kinases (Src-PTKs) during CNS myelination. QKI selectively interacted with the mRNA encoding the myelin basic protein (MBP). Such interaction stabilized MBP mRNA and was required for the rapid accumulation of MBP mRNA during active myelinogenesis. We found that the interaction between QKI and MBP mRNA was negatively regulated by Src-PTK-dependent phosphorylation of QKI. During early myelin development, tyrosine phosphorylation of QKI in the developing myelin drastically declined, presumably leading to enhanced interactions between QKI and MBP mRNA, which was associated with the rapid accumulation of MBP mRNA and accelerated myelin production. Therefore, developmental regulation of Src-PTK-dependent tyrosine phosphorylation of QKI suggests a novel mechanism for accelerating CNS myelinogenesis via regulating mRNA metabolism." @default.
• W2121932212 created "2016-06-24" @default.
• W2121932212 creator A5031561437 @default.
• W2121932212 date "2003-04-15" @default.
• W2121932212 modified "2023-10-10" @default.
• W2121932212 title "Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism" @default.
• W2121932212 cites W1551092739 @default.
• W2121932212 cites W1850765736 @default.
• W2121932212 cites W1924764088 @default.
• W2121932212 cites W1934896939 @default.
• W2121932212 cites W1968374866 @default.
• W2121932212 cites W1970878624 @default.
• W2121932212 cites W1989403911 @default.
• W2121932212 cites W1991449336 @default.
• W2121932212 cites W1998176244 @default.
• W2121932212 cites W2018233879 @default.
• W2121932212 cites W2019343236 @default.
• W2121932212 cites W2025366173 @default.
• W2121932212 cites W2025893957 @default.
• W2121932212 cites W2026446377 @default.
• W2121932212 cites W2036338927 @default.
• W2121932212 cites W2036894544 @default.
• W2121932212 cites W2042100636 @default.
• W2121932212 cites W2042270905 @default.
• W2121932212 cites W2057196350 @default.
• W2121932212 cites W2059016275 @default.
• W2121932212 cites W2064206062 @default.
• W2121932212 cites W2066337898 @default.
• W2121932212 cites W2067020273 @default.
• W2121932212 cites W2069617030 @default.
• W2121932212 cites W2076968004 @default.
• W2121932212 cites W2078897717 @default.
• W2121932212 cites W2079832984 @default.
• W2121932212 cites W2080349922 @default.
• W2121932212 cites W2080467864 @default.
• W2121932212 cites W2095363748 @default.
• W2121932212 cites W2099503180 @default.
• W2121932212 cites W2117841430 @default.
• W2121932212 cites W2118284390 @default.
• W2121932212 cites W2125050318 @default.
• W2121932212 cites W2126690485 @default.
• W2121932212 cites W2138811970 @default.
• W2121932212 cites W2141824178 @default.
• W2121932212 cites W2151814085 @default.
• W2121932212 cites W2164239948 @default.
• W2121932212 cites W2168788116 @default.
• W2121932212 cites W2170090906 @default.
• W2121932212 cites W27946189 @default.
• W2121932212 cites W71340409 @default.
• W2121932212 doi "https://doi.org/10.1093/emboj/cdg171" @default.
• W2121932212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/154463" @default.
• W2121932212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12682013" @default.
• W2121932212 hasPublicationYear "2003" @default.
• W2121932212 type Work @default.
• W2121932212 sameAs 2121932212 @default.
• W2121932212 citedByCount "69" @default.
• W2121932212 countsByYear W21219322122012 @default.
• W2121932212 countsByYear W21219322122013 @default.
• W2121932212 countsByYear W21219322122014 @default.
• W2121932212 countsByYear W21219322122016 @default.
• W2121932212 countsByYear W21219322122017 @default.
• W2121932212 countsByYear W21219322122019 @default.
• W2121932212 countsByYear W21219322122020 @default.
• W2121932212 countsByYear W21219322122021 @default.
• W2121932212 countsByYear W21219322122022 @default.
• W2121932212 countsByYear W21219322122023 @default.
• W2121932212 crossrefType "journal-article" @default.
• W2121932212 hasAuthorship W2121932212A5031561437 @default.
• W2121932212 hasBestOaLocation W21219322121 @default.
• W2121932212 hasConcept C104317684 @default.
• W2121932212 hasConcept C105580179 @default.
• W2121932212 hasConcept C108636557 @default.
• W2121932212 hasConcept C11960822 @default.
• W2121932212 hasConcept C169760540 @default.
• W2121932212 hasConcept C2776165026 @default.
• W2121932212 hasConcept C2776985911 @default.
• W2121932212 hasConcept C2777553839 @default.
• W2121932212 hasConcept C2778609137 @default.
• W2121932212 hasConcept C2780064007 @default.
• W2121932212 hasConcept C2780876595 @default.
• W2121932212 hasConcept C41282012 @default.
• W2121932212 hasConcept C529278444 @default.
• W2121932212 hasConcept C55493867 @default.
• W2121932212 hasConcept C62478195 @default.
• W2121932212 hasConcept C85528070 @default.
• W2121932212 hasConcept C86803240 @default.
• W2121932212 hasConcept C95444343 @default.
• W2121932212 hasConceptScore W2121932212C104317684 @default.
• W2121932212 hasConceptScore W2121932212C105580179 @default.
• W2121932212 hasConceptScore W2121932212C108636557 @default.
• W2121932212 hasConceptScore W2121932212C11960822 @default.
• W2121932212 hasConceptScore W2121932212C169760540 @default.
• W2121932212 hasConceptScore W2121932212C2776165026 @default.
• W2121932212 hasConceptScore W2121932212C2776985911 @default.
• W2121932212 hasConceptScore W2121932212C2777553839 @default.
• W2121932212 hasConceptScore W2121932212C2778609137 @default.
• W2121932212 hasConceptScore W2121932212C2780064007 @default.
• W2121932212 hasConceptScore W2121932212C2780876595 @default.

• next