Matches in SemOpenAlex for { <https://semopenalex.org/work/W2121972011> ?p ?o ?g. }
- W2121972011 endingPage "G81" @default.
- W2121972011 startingPage "G73" @default.
- W2121972011 abstract "Helicobacter pylori evades host immune defenses and causes chronic gastritis. Immunity against intestinal pathogens is largely mediated by dendritic cells, yet the role of dendritic cells in acute H. pylori infection is largely unknown. We observed the recruitment of dendritic cells to the gastric mucosa of H. pylori-infected mice. Bone marrow-derived dendritic cells from mice responded to live H. pylori by upregulating the expression of proinflammatory cytokine mRNA (i.e., IL-1α, IL-1β, and IL-6). The supernatant from dendritic cells stimulated with H. pylori for 18 h contained twofold higher levels of IL-12p70 than IL-10 and induced the proliferation of syngeneic splenocytes and type 1 T helper cell cytokine release (IFN-γ and TNF-α). These responses were significantly lower compared with those induced by Acinetobacter lwoffi, another gastritis-causing pathogen more susceptible to host defenses. Analysis of whole H. pylori sonicate revealed the presence of a heat-stable factor secreted from H. pylori that specifically inhibited IL-12 but not IL-10 release from dendritic cells activated by A. lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization." @default.
- W2121972011 created "2016-06-24" @default.
- W2121972011 creator A5003693281 @default.
- W2121972011 creator A5040175701 @default.
- W2121972011 creator A5042603101 @default.
- W2121972011 creator A5049458323 @default.
- W2121972011 creator A5052974914 @default.
- W2121972011 creator A5066157304 @default.
- W2121972011 creator A5071512976 @default.
- W2121972011 creator A5071949521 @default.
- W2121972011 date "2006-07-01" @default.
- W2121972011 modified "2023-10-18" @default.
- W2121972011 title "<i>Helicobacter pylori</i>-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense" @default.
- W2121972011 cites W1486555624 @default.
- W2121972011 cites W1540808432 @default.
- W2121972011 cites W1556987335 @default.
- W2121972011 cites W1561530553 @default.
- W2121972011 cites W1624186839 @default.
- W2121972011 cites W1845975704 @default.
- W2121972011 cites W1995212789 @default.
- W2121972011 cites W2002854478 @default.
- W2121972011 cites W2007480254 @default.
- W2121972011 cites W2022948175 @default.
- W2121972011 cites W2040857027 @default.
- W2121972011 cites W2050828970 @default.
- W2121972011 cites W2063666087 @default.
- W2121972011 cites W2071018915 @default.
- W2121972011 cites W2079027104 @default.
- W2121972011 cites W2085706963 @default.
- W2121972011 cites W2095015833 @default.
- W2121972011 cites W2097071287 @default.
- W2121972011 cites W2103152340 @default.
- W2121972011 cites W2104503051 @default.
- W2121972011 cites W2108583998 @default.
- W2121972011 cites W2110211464 @default.
- W2121972011 cites W2112345055 @default.
- W2121972011 cites W2118209538 @default.
- W2121972011 cites W2126528152 @default.
- W2121972011 cites W2132086644 @default.
- W2121972011 cites W2135069147 @default.
- W2121972011 cites W2137610232 @default.
- W2121972011 cites W2157808055 @default.
- W2121972011 cites W2159207062 @default.
- W2121972011 cites W2160014515 @default.
- W2121972011 cites W2161360952 @default.
- W2121972011 cites W2162373315 @default.
- W2121972011 cites W2166141110 @default.
- W2121972011 cites W2169383056 @default.
- W2121972011 cites W2327597225 @default.
- W2121972011 doi "https://doi.org/10.1152/ajpgi.00139.2005" @default.
- W2121972011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16469828" @default.
- W2121972011 hasPublicationYear "2006" @default.
- W2121972011 type Work @default.
- W2121972011 sameAs 2121972011 @default.
- W2121972011 citedByCount "80" @default.
- W2121972011 countsByYear W21219720112012 @default.
- W2121972011 countsByYear W21219720112013 @default.
- W2121972011 countsByYear W21219720112014 @default.
- W2121972011 countsByYear W21219720112015 @default.
- W2121972011 countsByYear W21219720112016 @default.
- W2121972011 countsByYear W21219720112017 @default.
- W2121972011 countsByYear W21219720112018 @default.
- W2121972011 countsByYear W21219720112019 @default.
- W2121972011 countsByYear W21219720112020 @default.
- W2121972011 countsByYear W21219720112021 @default.
- W2121972011 countsByYear W21219720112022 @default.
- W2121972011 countsByYear W21219720112023 @default.
- W2121972011 crossrefType "journal-article" @default.
- W2121972011 hasAuthorship W2121972011A5003693281 @default.
- W2121972011 hasAuthorship W2121972011A5040175701 @default.
- W2121972011 hasAuthorship W2121972011A5042603101 @default.
- W2121972011 hasAuthorship W2121972011A5049458323 @default.
- W2121972011 hasAuthorship W2121972011A5052974914 @default.
- W2121972011 hasAuthorship W2121972011A5066157304 @default.
- W2121972011 hasAuthorship W2121972011A5071512976 @default.
- W2121972011 hasAuthorship W2121972011A5071949521 @default.
- W2121972011 hasConcept C149532602 @default.
- W2121972011 hasConcept C154317977 @default.
- W2121972011 hasConcept C164027704 @default.
- W2121972011 hasConcept C187316574 @default.
- W2121972011 hasConcept C202751555 @default.
- W2121972011 hasConcept C203014093 @default.
- W2121972011 hasConcept C2776409635 @default.
- W2121972011 hasConcept C2776914184 @default.
- W2121972011 hasConcept C2778170410 @default.
- W2121972011 hasConcept C2778690821 @default.
- W2121972011 hasConcept C49039625 @default.
- W2121972011 hasConcept C54355233 @default.
- W2121972011 hasConcept C55493867 @default.
- W2121972011 hasConcept C86803240 @default.
- W2121972011 hasConcept C8891405 @default.
- W2121972011 hasConcept C89423630 @default.
- W2121972011 hasConceptScore W2121972011C149532602 @default.
- W2121972011 hasConceptScore W2121972011C154317977 @default.
- W2121972011 hasConceptScore W2121972011C164027704 @default.
- W2121972011 hasConceptScore W2121972011C187316574 @default.
- W2121972011 hasConceptScore W2121972011C202751555 @default.
- W2121972011 hasConceptScore W2121972011C203014093 @default.