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- W2121974077 abstract "IN 1934 Trendelenburg, reviewing the early literature, stated that thyroidectomy in the dog results in a pronounced inhibition of skeletal growth in addition to other changes. In recent years, however, several reports have appeared (Danowski, Man and Winkler, 1946; Glock, 1949; Binswanger, 1936) indicating that the usual manifestations of hypothyroidism do not develop in dogs in which thyroid deficiency is induced either by surgical excision of the gland or by thiouracil administration. Even though Glock found an increased serum cholesterol as well as histological alterations in the thyroid and anterior hypophysis of thiouracil-treated dogs, she did not observe behavioral or myxedematous changes, growth impairment (puppies), or marked decline in metabolic rate. A striking study is that of Mayer (1947) who concluded “that beagles, and probably most dogs, do not need the thyroid function under ordinary conditions.” After administering propylthiouracil to pure-bred beagle puppies, he failed to observe any im..." @default.
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- W2121974077 date "1952-01-01" @default.
- W2121974077 modified "2023-09-27" @default.
- W2121974077 title "MYXEDEMA IN THE RADIOTHYROIDECTOMIZED DOG1" @default.
- W2121974077 doi "https://doi.org/10.1210/endo-50-1-115" @default.
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