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- W2122000775 abstract "Melanocytes can give rise to a variety of benign and malignant neoplasms that differ in their appearance and, more importantly, in their biological behavior. Melanocytic nevi are self-limited proliferations of melanocytes, whereas melanocytes in melanoma continue to proliferate and therefore constitute a severe threat to the host. There is emerging evidence that the initiating events, such as mutations in oncogenes, such as BRAF and RAS, may be similar in nevi and melanoma. However, the exact nature of the mechanism that restricts proliferation in nevi that presumably fails in melanoma is currently unclear. Among melanomas, clinical and histopathological presentation can vary significantly. Several factors, such as anatomic location, sun-exposure patterns, and patient age have been associated with different histopathological and clinical patterns of melanoma (1,2). In this chapter, I review genetic changes in different types of nevi and melanomas and discuss potential biological consequences and possible impacts on classification and therapy." @default.
- W2122000775 created "2016-06-24" @default.
- W2122000775 creator A5039942885 @default.
- W2122000775 date "2007-11-04" @default.
- W2122000775 modified "2023-09-28" @default.
- W2122000775 title "Genetic Progression From Melanocyte to Malignant Melanoma" @default.
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- W2122000775 doi "https://doi.org/10.1007/978-1-59259-994-3_11" @default.
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