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- W2122001808 abstract "You have accessJournal of UrologyBenign Prostatic Hyperplasia: Evaluation and Symptoms1 Apr 2015MP71-08 METABOLIC PROFILE CAN BE A LEADING PATHOGENETIC FACTOR FOR BENIGN PROSTATIC ENLARGEMENT Mauro Gacci, Matteo Salvi, Arcangelo Sebastianelli, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini, and Sergio Serni Mauro GacciMauro Gacci More articles by this author , Matteo SalviMatteo Salvi More articles by this author , Arcangelo SebastianelliArcangelo Sebastianelli More articles by this author , Cosimo De NunzioCosimo De Nunzio More articles by this author , Linda VignozziLinda Vignozzi More articles by this author , Giovanni CoronaGiovanni Corona More articles by this author , Tommaso JaegerTommaso Jaeger More articles by this author , Tommaso ChiniTommaso Chini More articles by this author , Giorgio Ivan RussoGiorgio Ivan Russo More articles by this author , Mario MaggiMario Maggi More articles by this author , Giuseppe MorgiaGiuseppe Morgia More articles by this author , Andrea TubaroAndrea Tubaro More articles by this author , Marco CariniMarco Carini More articles by this author , and Sergio SerniSergio Serni More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2621AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Metabolic syndrome (MetS), can be associated with the development of benign prostatic enlargement (BPE). Recent studies underlined the close association of several MetS components and benign prostatic enlargement (BPE). Aim of our study was to evaluate the correlations between the occurrence of MetS and prostate's measures of men surgically treated for BPE METHODS Between January 2012 and October 2013, we conducted a multicenter prospective study evaluating 379 consecutive men undergone surgery for severe LUTS due to BPE. Suprapubic US was used to calculate prostate raw volume (PV), by using the “estimated ellipsoid volume” based on circumference, while transrectal US was use to mesure the calculated PV, with defining the antero-posterior (AP), the cranio-caudal (CC) and the latero-lateral (LL) diameters through the ellipsoid formula (D1xD2xD3xπ/6). MetS was defined according to the US National Cholesterol Education Program-Adult Treatment Panel III RESULTS One hundred and forty men (36.9%) were affected by MetS. At the binary logistic regression, calculated with all the main determinants of PV, including age, BMI, use of 5-alpha-reductase inhibitors, MetS resulted the single risk factor for large (>60cc) raw and calculated PV (OR: 2.43 [95% CI: 1.44-4.09), p=0.001 and OR:4.28 [95% CI:2.15-8.52), p<0.001, respectively). The number of MetS parameters, was related with the calculated PV (r=0.244, p=0.001, see Fig1A), with the AP (r=0.231, p=0.002), the CC (r=0.192, p=0.009) and the LL diameter (r=0.171, p=0.020). Moreover, at multivariate analysis the AP diameter was mainly correlated with HDL cholesterol (adjusted r for age, BMI and 5-ARIs: -0.3103, p=0.002, see fig1B), the CC diameter with triglycerides (adjusted r:-0.191, p=0.050, see fig1C) and the LL diameter with systolic blood pressure (adjusted r: 0.154, p=0.044, see fig1D). However, the binary logistic regression adjusted for age, MetS, smoke and the assumption of 5ARI, based on the median prostate diameters, revealed that low HDL Cholesterol was the central determinant for the enlargement of whole PV, as a result of every prostate diameter growing. CONCLUSIONS Metabolic factors, in particular dyslipidemia with low HDL Cholesterol, could play a critical role in the pathogenesis and progression of BPE, leading to a significant increase of PV © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e914 Peer Review Report Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mauro Gacci More articles by this author Matteo Salvi More articles by this author Arcangelo Sebastianelli More articles by this author Cosimo De Nunzio More articles by this author Linda Vignozzi More articles by this author Giovanni Corona More articles by this author Tommaso Jaeger More articles by this author Tommaso Chini More articles by this author Giorgio Ivan Russo More articles by this author Mario Maggi More articles by this author Giuseppe Morgia More articles by this author Andrea Tubaro More articles by this author Marco Carini More articles by this author Sergio Serni More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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- W2122001808 title "MP71-08 METABOLIC PROFILE CAN BE A LEADING PATHOGENETIC FACTOR FOR BENIGN PROSTATIC ENLARGEMENT" @default.
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