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• W2122006414 abstract "The review focuses on the central neuronal circuits involved in energy homeostasis and the opportunities these offer for pharmacological intervention to decrease feeding behaviour and reduce weight. This article is based on the presentation ‘ New central targets for the treatment of obesity ’ (Sargent, British Pharmacological society, Clinical Section Symposium, December 2008). Central neuronal substrates controlling weight offer numerous opportunities for pharmacological intervention. These opportunities range from non‐specific enhancement of monoamine signalling (triple reuptake inhibitors) to targeting specific monoamine receptor subtypes (5‐HT 2c and 5‐HT 6 ). The data reviewed suggest that these approaches will lead to weight loss; whether this is sufficient to produce clinically meaningful effect remains to be determined. Combination therapy targeting more than one mechanism may be a means of increasing the magnitude of the response. Preclinical studies also suggest that novel approaches targeting specific neuronal pathways within the hypothalamus, e.g. MCH 1 receptor antagonism, offer an opportunity for weight reduction. However, these approaches are at an early stage and clinical studies will be needed to determine if these novel approaches lead to clinically meaningful weight loss and improvements in co‐morbid conditions such as diabetes and cardiovascular disorders." @default.
• W2122006414 created "2016-06-24" @default.
• W2122006414 creator A5021048548 @default.
• W2122006414 creator A5061329458 @default.
• W2122006414 date "2009-11-27" @default.
• W2122006414 modified "2023-10-17" @default.
• W2122006414 title "New central targets for the treatment of obesity" @default.
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• W2122006414 doi "https://doi.org/10.1111/j.1365-2125.2009.03550.x" @default.
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