Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122006959> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2122006959 endingPage "23" @default.
- W2122006959 startingPage "21" @default.
- W2122006959 abstract "With the advent of more intensive glucose management, hypoglycemia has emerged as a primary limitation in the treatment of insulin-dependent diabetes. It is now recognized that the increased incidence of hypoglycemia derives not only from imperfect insulin replacement but also from impaired counterregulation and hypoglycemic unawareness (1). The latter two observations have led to a renewed interest in the mechanisms underlying hypoglycemic detection. As a result of intensive research over the past decade, the traditional hypothalamocentric model of glucose sensing has been replaced with one emphasizing a widespread neural network involving numerous aspects of the central nervous system, as well as peripheral sensory input. Thus, in addition to the ventromedial hypothalamus, the paraventricular hypothalamus, arcuate nucleus, area postrema, nucleus of the solitary tract, and dorsal motor nucleus all appear to play important roles (2,3). In the periphery, important glucose sensors have been identified in the carotid bodies (4), gastrointestinal tract (5), and portal-mesenteric vein (6). For hypoglycemic detection, the glucose sensors of the portal-mesenteric vein have garnered the most attention. Animal studies have repeatedly demonstrated that blocking portal glucose sensing via portal glucose infusion (7) or denervating the portal vein (8) substantially suppresses the sympathoadrenal response to hypoglycemia. More recently, it was shown that portal-mesenteric vein glucose sensing is particularly important when hypoglycemia develops slowly and, under these conditions, modulates over 90% of the sympathoadrenal response to hypoglycemia (9).While portal …" @default.
- W2122006959 created "2016-06-24" @default.
- W2122006959 creator A5021101019 @default.
- W2122006959 creator A5054009279 @default.
- W2122006959 date "2009-01-01" @default.
- W2122006959 modified "2023-09-27" @default.
- W2122006959 title "Hypoglycemic Detection at the Portal Vein" @default.
- W2122006959 cites W1569037784 @default.
- W2122006959 cites W2003377672 @default.
- W2122006959 cites W2006964476 @default.
- W2122006959 cites W2021945837 @default.
- W2122006959 cites W2023860909 @default.
- W2122006959 cites W2079595686 @default.
- W2122006959 cites W2081663675 @default.
- W2122006959 cites W2106185634 @default.
- W2122006959 cites W2120292775 @default.
- W2122006959 cites W2145594694 @default.
- W2122006959 cites W2147947586 @default.
- W2122006959 cites W2149746290 @default.
- W2122006959 cites W2154391117 @default.
- W2122006959 cites W2155481474 @default.
- W2122006959 cites W2158608859 @default.
- W2122006959 cites W2172204314 @default.
- W2122006959 cites W2181947976 @default.
- W2122006959 cites W2263110873 @default.
- W2122006959 cites W4242300597 @default.
- W2122006959 doi "https://doi.org/10.2337/db08-1437" @default.
- W2122006959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2606875" @default.
- W2122006959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19114726" @default.
- W2122006959 hasPublicationYear "2009" @default.
- W2122006959 type Work @default.
- W2122006959 sameAs 2122006959 @default.
- W2122006959 citedByCount "8" @default.
- W2122006959 countsByYear W21220069592012 @default.
- W2122006959 countsByYear W21220069592013 @default.
- W2122006959 countsByYear W21220069592014 @default.
- W2122006959 countsByYear W21220069592015 @default.
- W2122006959 countsByYear W21220069592023 @default.
- W2122006959 crossrefType "journal-article" @default.
- W2122006959 hasAuthorship W2122006959A5021101019 @default.
- W2122006959 hasAuthorship W2122006959A5054009279 @default.
- W2122006959 hasBestOaLocation W21220069591 @default.
- W2122006959 hasConcept C126322002 @default.
- W2122006959 hasConcept C164705383 @default.
- W2122006959 hasConcept C2779033008 @default.
- W2122006959 hasConcept C71924100 @default.
- W2122006959 hasConceptScore W2122006959C126322002 @default.
- W2122006959 hasConceptScore W2122006959C164705383 @default.
- W2122006959 hasConceptScore W2122006959C2779033008 @default.
- W2122006959 hasConceptScore W2122006959C71924100 @default.
- W2122006959 hasIssue "1" @default.
- W2122006959 hasLocation W21220069591 @default.
- W2122006959 hasLocation W21220069592 @default.
- W2122006959 hasLocation W21220069593 @default.
- W2122006959 hasLocation W21220069594 @default.
- W2122006959 hasOpenAccess W2122006959 @default.
- W2122006959 hasPrimaryLocation W21220069591 @default.
- W2122006959 hasRelatedWork W1991544234 @default.
- W2122006959 hasRelatedWork W2076570867 @default.
- W2122006959 hasRelatedWork W2280098374 @default.
- W2122006959 hasRelatedWork W2345216176 @default.
- W2122006959 hasRelatedWork W2391400659 @default.
- W2122006959 hasRelatedWork W2416634033 @default.
- W2122006959 hasRelatedWork W2577066731 @default.
- W2122006959 hasRelatedWork W4242805618 @default.
- W2122006959 hasRelatedWork W4312196537 @default.
- W2122006959 hasRelatedWork W4322722689 @default.
- W2122006959 hasVolume "58" @default.
- W2122006959 isParatext "false" @default.
- W2122006959 isRetracted "false" @default.
- W2122006959 magId "2122006959" @default.
- W2122006959 workType "article" @default.