FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122009877> ?p ?o ?g. }

• W2122009877 endingPage "995" @default.
• W2122009877 startingPage "987" @default.
• W2122009877 abstract "ABSTRACT A positive relationship between receptor concentration and tissue responsiveness is an often-assumed and rarely tested principle in endocrinology. In salmonids, seasonal changes in levels of plasma cortisol and gill corticosteroid receptors (CRs) during the spring indicate a potential role for this hormone in the parr–smolt transformation. It is not known whether these seasonal changes result in alterations in gill responsiveness to cortisol. The relationship between CR concentration and tissue responsiveness was, therefore, examined in the gills of juvenile rainbow trout (Oncorhynchus mykiss). Gill CR concentration (Bmax) and affinity (Kd) were assessed using a radioligand binding assay with the synthetic glucocorticoid triamcinolone acetonide. Gill responsiveness to cortisol was quantified by measuring in vitro Na+/K+-ATPase activity. Gill CR concentration was manipulated by stress or hormonal treatments. Repeated handling stresses resulted in a significant reduction in CR numbers. The decrease in CR Bmax corresponded to a reduction in gill responsiveness to cortisol. Triiodothyronine, but not growth hormone, treatment was found to increase CR Bmax significantly. The increase in CR numbers was correlated with a marked increase in gill responsiveness to cortisol. A significant positive linear relationship exists between the in vitro gill Na+/K+-ATPase activity response to cortisol and CR Bmax (r2=0.614, P&lt;0.001). We have demonstrated that binding sites for cortisol in the gills of rainbow trout have high affinity, high specificity and saturable binding and that the number of binding sites is correlated with the tissue response to cortisol." @default.
• W2122009877 created "2016-06-24" @default.
• W2122009877 creator A5038468213 @default.
• W2122009877 creator A5047037816 @default.
• W2122009877 date "1999-04-15" @default.
• W2122009877 modified "2023-10-08" @default.
• W2122009877 title "Responsiveness of gill Na+/K+-ATPase to cortisol is related to gill corticosteroid receptor concentration in juvenile rainbow trout" @default.
• W2122009877 cites W1543106250 @default.
• W2122009877 cites W1545957512 @default.
• W2122009877 cites W1972958136 @default.
• W2122009877 cites W1980469657 @default.
• W2122009877 cites W1980839241 @default.
• W2122009877 cites W1982927366 @default.
• W2122009877 cites W1983649348 @default.
• W2122009877 cites W1991101593 @default.
• W2122009877 cites W1999841552 @default.
• W2122009877 cites W2002864309 @default.
• W2122009877 cites W2004600519 @default.
• W2122009877 cites W2005668937 @default.
• W2122009877 cites W2005878689 @default.
• W2122009877 cites W2011604951 @default.
• W2122009877 cites W2015738213 @default.
• W2122009877 cites W2016640892 @default.
• W2122009877 cites W2019767633 @default.
• W2122009877 cites W2023294979 @default.
• W2122009877 cites W2023489889 @default.
• W2122009877 cites W2024542975 @default.
• W2122009877 cites W2027883508 @default.
• W2122009877 cites W2031159199 @default.
• W2122009877 cites W2031559647 @default.
• W2122009877 cites W2039602019 @default.
• W2122009877 cites W2050710240 @default.
• W2122009877 cites W2051678363 @default.
• W2122009877 cites W2057163861 @default.
• W2122009877 cites W2061196213 @default.
• W2122009877 cites W2065152627 @default.
• W2122009877 cites W2070402931 @default.
• W2122009877 cites W2076466803 @default.
• W2122009877 cites W2079939265 @default.
• W2122009877 cites W2106470286 @default.
• W2122009877 cites W2166141412 @default.
• W2122009877 cites W2170743516 @default.
• W2122009877 cites W4293247451 @default.
• W2122009877 doi "https://doi.org/10.1242/jeb.202.8.987" @default.
• W2122009877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10085271" @default.
• W2122009877 hasPublicationYear "1999" @default.
• W2122009877 type Work @default.
• W2122009877 sameAs 2122009877 @default.
• W2122009877 citedByCount "90" @default.
• W2122009877 countsByYear W21220098772012 @default.
• W2122009877 countsByYear W21220098772013 @default.
• W2122009877 countsByYear W21220098772014 @default.
• W2122009877 countsByYear W21220098772015 @default.
• W2122009877 countsByYear W21220098772016 @default.
• W2122009877 countsByYear W21220098772017 @default.
• W2122009877 countsByYear W21220098772018 @default.
• W2122009877 countsByYear W21220098772020 @default.
• W2122009877 countsByYear W21220098772021 @default.
• W2122009877 countsByYear W21220098772023 @default.
• W2122009877 crossrefType "journal-article" @default.
• W2122009877 hasAuthorship W2122009877A5038468213 @default.
• W2122009877 hasAuthorship W2122009877A5047037816 @default.
• W2122009877 hasConcept C126322002 @default.
• W2122009877 hasConcept C134018914 @default.
• W2122009877 hasConcept C161153951 @default.
• W2122009877 hasConcept C170493617 @default.
• W2122009877 hasConcept C203014093 @default.
• W2122009877 hasConcept C2776804153 @default.
• W2122009877 hasConcept C2778709874 @default.
• W2122009877 hasConcept C2778903070 @default.
• W2122009877 hasConcept C2779363728 @default.
• W2122009877 hasConcept C2780841215 @default.
• W2122009877 hasConcept C2909208804 @default.
• W2122009877 hasConcept C2994167347 @default.
• W2122009877 hasConcept C505870484 @default.
• W2122009877 hasConcept C59493245 @default.
• W2122009877 hasConcept C71315377 @default.
• W2122009877 hasConcept C71924100 @default.
• W2122009877 hasConcept C86803240 @default.
• W2122009877 hasConceptScore W2122009877C126322002 @default.
• W2122009877 hasConceptScore W2122009877C134018914 @default.
• W2122009877 hasConceptScore W2122009877C161153951 @default.
• W2122009877 hasConceptScore W2122009877C170493617 @default.
• W2122009877 hasConceptScore W2122009877C203014093 @default.
• W2122009877 hasConceptScore W2122009877C2776804153 @default.
• W2122009877 hasConceptScore W2122009877C2778709874 @default.
• W2122009877 hasConceptScore W2122009877C2778903070 @default.
• W2122009877 hasConceptScore W2122009877C2779363728 @default.
• W2122009877 hasConceptScore W2122009877C2780841215 @default.
• W2122009877 hasConceptScore W2122009877C2909208804 @default.
• W2122009877 hasConceptScore W2122009877C2994167347 @default.
• W2122009877 hasConceptScore W2122009877C505870484 @default.
• W2122009877 hasConceptScore W2122009877C59493245 @default.
• W2122009877 hasConceptScore W2122009877C71315377 @default.
• W2122009877 hasConceptScore W2122009877C71924100 @default.
• W2122009877 hasConceptScore W2122009877C86803240 @default.
• W2122009877 hasIssue "8" @default.
• W2122009877 hasLocation W21220098771 @default.

• next