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- W2122012022 abstract "correlating the effect size of the treatment on OS with the corresponding effect size on the surrogate endpoint. Strong congruence of the effect sizes of the two endpoints supports the premise that the surrogate endpoint is a valid replacement for OS, although the strength of the statistical measure can be strongly dependent on the range of effect sizes observed in the historical studies. The meta-analysis of Oba et al. demonstrates impressively close concordance of the effects of treatment on OS and DFS from 14 historical adjuvant trials of gastric cancer (5). These results exemplify the fact that in the adjuvant setting disease recurrence is a pivotal event in the natural history of the disease for most solid tumors. Recurrence predicts strongly ultimate death from disease. Indeed the rank correlation between DFS" @default.
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- W2122012022 date "2013-10-09" @default.
- W2122012022 modified "2023-09-27" @default.
- W2122012022 title "Justifying the Choice of Endpoints for Clinical Trials" @default.
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- W2122012022 doi "https://doi.org/10.1093/jnci/djt289" @default.
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