FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122017112> ?p ?o ?g. }

• W2122017112 endingPage "G497" @default.
• W2122017112 startingPage "G487" @default.
• W2122017112 abstract "The macrophage plays a major role in the induction and resolution phases of inflammation; however, how lipid mediator-derived signals may modulate macrophage function in the resolution of inflammation driven by microbes (e.g., in inflammatory bowel disease) is not well understood. We examined the effects of aspirin-triggered lipoxin (ATL), a stable analog of lipoxin A(4), on the antimicrobial responses of human peripheral blood mononuclear cell-derived macrophages and the monocytic THP-1 cell line. Additionally, we assessed the expression and localization of the lipoxin receptor, formyl peptide receptor 2 (FPR2), in colonic mucosal biopsies from patients with Crohn's disease to determine whether the capacity for lipoxin signaling is altered in inflammatory bowel disease. We found that THP-1 cells treated with ATL (100 nM) displayed increased phagocytosis of inert fluorescent beads and Escherichia coli in a scavenger receptor- and PI3K-dependent, opsonization-independent manner. This ATL-induced increase in phagocytosis was also observed in primary human macrophages, where it was associated with an inhibition of E. coli-induced IL-1β and IL-8 production. Finally, we found that FPR2 gene expression was increased approximately sixfold in the colon of patients with Crohn's disease, a finding reproduced in vitro by the treatment of THP-1 cells with interferon-γ or lipopolysaccharide. These results suggest that lipoxin signaling is upregulated in inflammatory environments, and, in addition to their known role in tissue resolution following injury, lipoxins can enhance macrophage clearance of invading microbes." @default.
• W2122017112 created "2016-06-24" @default.
• W2122017112 creator A5000539009 @default.
• W2122017112 creator A5058878946 @default.
• W2122017112 date "2011-09-01" @default.
• W2122017112 modified "2023-10-14" @default.
• W2122017112 title "Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production" @default.
• W2122017112 cites W141685425 @default.
• W2122017112 cites W1497700962 @default.
• W2122017112 cites W1531140346 @default.
• W2122017112 cites W1539625195 @default.
• W2122017112 cites W1552747622 @default.
• W2122017112 cites W1561369138 @default.
• W2122017112 cites W1591358437 @default.
• W2122017112 cites W1593158742 @default.
• W2122017112 cites W1601002338 @default.
• W2122017112 cites W1767991896 @default.
• W2122017112 cites W1968167945 @default.
• W2122017112 cites W1969284893 @default.
• W2122017112 cites W1986734670 @default.
• W2122017112 cites W1994957003 @default.
• W2122017112 cites W2015141049 @default.
• W2122017112 cites W2015271251 @default.
• W2122017112 cites W2016293419 @default.
• W2122017112 cites W2018167120 @default.
• W2122017112 cites W2018343427 @default.
• W2122017112 cites W2029686125 @default.
• W2122017112 cites W2034285135 @default.
• W2122017112 cites W2048007675 @default.
• W2122017112 cites W2048565177 @default.
• W2122017112 cites W2052085748 @default.
• W2122017112 cites W2054895562 @default.
• W2122017112 cites W2071201771 @default.
• W2122017112 cites W2073059894 @default.
• W2122017112 cites W2074830652 @default.
• W2122017112 cites W2075145828 @default.
• W2122017112 cites W2078621117 @default.
• W2122017112 cites W2086790252 @default.
• W2122017112 cites W2097415922 @default.
• W2122017112 cites W2099788086 @default.
• W2122017112 cites W2102970270 @default.
• W2122017112 cites W2104460754 @default.
• W2122017112 cites W2104909111 @default.
• W2122017112 cites W2111790202 @default.
• W2122017112 cites W2113203684 @default.
• W2122017112 cites W2114570899 @default.
• W2122017112 cites W2119417945 @default.
• W2122017112 cites W2120699390 @default.
• W2122017112 cites W2127885803 @default.
• W2122017112 cites W2128627731 @default.
• W2122017112 cites W2128829928 @default.
• W2122017112 cites W2131368814 @default.
• W2122017112 cites W2138291177 @default.
• W2122017112 cites W2141344207 @default.
• W2122017112 cites W2153454088 @default.
• W2122017112 cites W2161329854 @default.
• W2122017112 cites W2164273883 @default.
• W2122017112 cites W2165872127 @default.
• W2122017112 cites W2166102027 @default.
• W2122017112 cites W2288245591 @default.
• W2122017112 cites W2425354067 @default.
• W2122017112 cites W4234615218 @default.
• W2122017112 cites W4313343390 @default.
• W2122017112 doi "https://doi.org/10.1152/ajpgi.00042.2011" @default.
• W2122017112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21659618" @default.
• W2122017112 hasPublicationYear "2011" @default.
• W2122017112 type Work @default.
• W2122017112 sameAs 2122017112 @default.
• W2122017112 citedByCount "49" @default.
• W2122017112 countsByYear W21220171122012 @default.
• W2122017112 countsByYear W21220171122013 @default.
• W2122017112 countsByYear W21220171122014 @default.
• W2122017112 countsByYear W21220171122015 @default.
• W2122017112 countsByYear W21220171122016 @default.
• W2122017112 countsByYear W21220171122018 @default.
• W2122017112 countsByYear W21220171122019 @default.
• W2122017112 countsByYear W21220171122020 @default.
• W2122017112 countsByYear W21220171122021 @default.
• W2122017112 countsByYear W21220171122022 @default.
• W2122017112 countsByYear W21220171122023 @default.
• W2122017112 crossrefType "journal-article" @default.
• W2122017112 hasAuthorship W2122017112A5000539009 @default.
• W2122017112 hasAuthorship W2122017112A5058878946 @default.
• W2122017112 hasConcept C160448771 @default.
• W2122017112 hasConcept C168261976 @default.
• W2122017112 hasConcept C170493617 @default.
• W2122017112 hasConcept C180899940 @default.
• W2122017112 hasConcept C185592680 @default.
• W2122017112 hasConcept C202751555 @default.
• W2122017112 hasConcept C203014093 @default.
• W2122017112 hasConcept C2776914184 @default.
• W2122017112 hasConcept C2778690821 @default.
• W2122017112 hasConcept C2778754761 @default.
• W2122017112 hasConcept C2779244956 @default.
• W2122017112 hasConcept C2780415110 @default.
• W2122017112 hasConcept C55493867 @default.
• W2122017112 hasConcept C86803240 @default.
• W2122017112 hasConcept C89423630 @default.

• next