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- W2122022809 endingPage "1308" @default.
- W2122022809 startingPage "1299" @default.
- W2122022809 abstract "Abstract Cholesterol and phospholipids serve as structural and functional components of cellular membranes in all eukaryotes. Heterogeneity in cholesterol and phospholipid content both within and between different organelles is an important characteristic of eukaryotic membranes. How this heterogeneity is achieved and orchestrated to maintain proper cellular physiology remains poorly understood. We previously found that overexpression of the Drosophilaoxysterol-binding protein (OSBP) leads to sterol accumulation in the Golgi apparatus. Here, we show that Osbp overexpression in a set of neuroendocrine neurons compromises the function of the Golgi apparatus. It impairs trafficking of the neuropeptide bursicon and results in post-eclosion behavior defects characterized by unexpanded wings. We performed a genetic screen to identify modifiers that suppress the unexpanded wing phenotype. A putative phospholipid flippase-encoding gene, CG33298, was validated, suggesting that a membrane-asymmetry-directed mechanism balances cholesterol chaos within the Golgi membranes. Since the functional connection between cholesterol metabolism and the activity of phospholipid flippase has been implicated in studies in yeast and worms, our findings here support an evolutionarily conserved causal link between cholesterol homeostasis and phospholipid asymmetry that maintains normal cellular physiology." @default.
- W2122022809 created "2016-06-24" @default.
- W2122022809 creator A5059343631 @default.
- W2122022809 creator A5074767068 @default.
- W2122022809 creator A5091105051 @default.
- W2122022809 date "2012-04-01" @default.
- W2122022809 modified "2023-10-18" @default.
- W2122022809 title "Membrane Phospholipid Asymmetry Counters the Adverse Effects of Sterol Overloading in the Golgi Membrane of Drosophila" @default.
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- W2122022809 doi "https://doi.org/10.1534/genetics.111.137687" @default.
- W2122022809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3316644" @default.
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