FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2122022984> ?p ?o ?g. }

• W2122022984 endingPage "515" @default.
• W2122022984 startingPage "507" @default.
• W2122022984 abstract "Ocular dominance plasticity (ODP) in the cat primary visual cortex (V1) is induced during waking by monocular deprivation (MD) and consolidated during subsequent sleep. The mechanisms underlying this process are incompletely understood. Extracellular signal-regulated kinase (ERK) is activated in V1 during sleep after MD, but it is unknown whether ERK activation during sleep is necessary for ODP consolidation. We investigated the role of ERK in sleep-dependent ODP consolidation by inhibiting the ERK-activating enzyme MEK in V1 (via U0126) during post-MD sleep. ODP consolidation was then measured with extracellular microelectrode recordings. Western blot analysis was used to confirm the efficacy of U0126 and to examine proteins downstream of ERK. U0126 abolished ODP consolidation and reduced both phosphorylation of eukaryotic initiation factor 4E (eIF4E) and levels of the synaptic marker PSD-95. Furthermore, interfering with ERK-mediated translation by inhibiting MAP kinase-interacting kinase 1 (Mnk1) with CGP57380 mimicked the effects of U0126. These results demonstrate that ODP consolidation requires sleep-dependent activation of the ERK-Mnk1 pathway." @default.
• W2122022984 created "2016-06-24" @default.
• W2122022984 creator A5003090989 @default.
• W2122022984 creator A5046150737 @default.
• W2122022984 creator A5051919903 @default.
• W2122022984 creator A5061970781 @default.
• W2122022984 creator A5069221667 @default.
• W2122022984 creator A5075095442 @default.
• W2122022984 date "2013-09-17" @default.
• W2122022984 modified "2023-10-16" @default.
• W2122022984 title "Extracellular Signal-Regulated Kinase (ERK) Activity During Sleep Consolidates Cortical Plasticity In Vivo" @default.
• W2122022984 cites W1539823279 @default.
• W2122022984 cites W1553096643 @default.
• W2122022984 cites W1554441317 @default.
• W2122022984 cites W1555945582 @default.
• W2122022984 cites W1839558765 @default.
• W2122022984 cites W1887094909 @default.
• W2122022984 cites W1937085587 @default.
• W2122022984 cites W2000560379 @default.
• W2122022984 cites W2014050156 @default.
• W2122022984 cites W2017764061 @default.
• W2122022984 cites W2018780716 @default.
• W2122022984 cites W2027813810 @default.
• W2122022984 cites W2030414484 @default.
• W2122022984 cites W2032666422 @default.
• W2122022984 cites W2053738369 @default.
• W2122022984 cites W2069705491 @default.
• W2122022984 cites W2072146699 @default.
• W2122022984 cites W2082304738 @default.
• W2122022984 cites W2086233863 @default.
• W2122022984 cites W2086262311 @default.
• W2122022984 cites W2091339773 @default.
• W2122022984 cites W2100699923 @default.
• W2122022984 cites W2102005912 @default.
• W2122022984 cites W2102889876 @default.
• W2122022984 cites W2104220712 @default.
• W2122022984 cites W2109851824 @default.
• W2122022984 cites W2124965245 @default.
• W2122022984 cites W2134736026 @default.
• W2122022984 cites W2136381335 @default.
• W2122022984 cites W2138141709 @default.
• W2122022984 cites W2140254301 @default.
• W2122022984 cites W2143742981 @default.
• W2122022984 cites W2146047911 @default.
• W2122022984 cites W2146702633 @default.
• W2122022984 cites W2161849272 @default.
• W2122022984 cites W2162400338 @default.
• W2122022984 cites W2171903257 @default.
• W2122022984 cites W2340946024 @default.
• W2122022984 cites W4248525927 @default.
• W2122022984 doi "https://doi.org/10.1093/cercor/bht250" @default.
• W2122022984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4303804" @default.
• W2122022984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24047601" @default.
• W2122022984 hasPublicationYear "2013" @default.
• W2122022984 type Work @default.
• W2122022984 sameAs 2122022984 @default.
• W2122022984 citedByCount "44" @default.
• W2122022984 countsByYear W21220229842014 @default.
• W2122022984 countsByYear W21220229842015 @default.
• W2122022984 countsByYear W21220229842016 @default.
• W2122022984 countsByYear W21220229842017 @default.
• W2122022984 countsByYear W21220229842018 @default.
• W2122022984 countsByYear W21220229842019 @default.
• W2122022984 countsByYear W21220229842020 @default.
• W2122022984 countsByYear W21220229842021 @default.
• W2122022984 countsByYear W21220229842022 @default.
• W2122022984 countsByYear W21220229842023 @default.
• W2122022984 crossrefType "journal-article" @default.
• W2122022984 hasAuthorship W2122022984A5003090989 @default.
• W2122022984 hasAuthorship W2122022984A5046150737 @default.
• W2122022984 hasAuthorship W2122022984A5051919903 @default.
• W2122022984 hasAuthorship W2122022984A5061970781 @default.
• W2122022984 hasAuthorship W2122022984A5069221667 @default.
• W2122022984 hasAuthorship W2122022984A5075095442 @default.
• W2122022984 hasBestOaLocation W21220229841 @default.
• W2122022984 hasConcept C169760540 @default.
• W2122022984 hasConcept C184235292 @default.
• W2122022984 hasConcept C185592680 @default.
• W2122022984 hasConcept C2779345533 @default.
• W2122022984 hasConcept C2781161787 @default.
• W2122022984 hasConcept C28406088 @default.
• W2122022984 hasConcept C48455012 @default.
• W2122022984 hasConcept C57074206 @default.
• W2122022984 hasConcept C6084040 @default.
• W2122022984 hasConcept C86803240 @default.
• W2122022984 hasConcept C95444343 @default.
• W2122022984 hasConceptScore W2122022984C169760540 @default.
• W2122022984 hasConceptScore W2122022984C184235292 @default.
• W2122022984 hasConceptScore W2122022984C185592680 @default.
• W2122022984 hasConceptScore W2122022984C2779345533 @default.
• W2122022984 hasConceptScore W2122022984C2781161787 @default.
• W2122022984 hasConceptScore W2122022984C28406088 @default.
• W2122022984 hasConceptScore W2122022984C48455012 @default.
• W2122022984 hasConceptScore W2122022984C57074206 @default.
• W2122022984 hasConceptScore W2122022984C6084040 @default.
• W2122022984 hasConceptScore W2122022984C86803240 @default.
• W2122022984 hasConceptScore W2122022984C95444343 @default.
• W2122022984 hasIssue "2" @default.

• next