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- W2122027821 abstract "The ability of immune-competent donor T cells to mediate a beneficial graft-versus-leukemia (GVL) effect was first identified in the setting of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematologic malignancies. Unfortunately, with the exception of chronic myelogenous leukemia and EBV-induced lymphoproliferative disease, allo-HSCT GVL lacks the potency to significantly affect disease progression or recurrence in most other hematologic malignancies. The inadequacy of a GVL effect using past approaches is particularly evident in patients with lymphoid malignancies. However, with the advent of improved gene transfer technology, genetically modified tumor-specific immune effectors have extended cellular immunotherapy to lymphoid malignancies. One promising strategy entails the introduction of genes encoding artificial receptors called chimeric antigen receptors (CARs), which redirect the specificity and function of immune effectors. CAR-modified T cells targeted to the B cell-specific CD19 antigen have demonstrated promising results in multiple early clinical trials, supporting further investigation in patients with B-cell cancers. However, disparities in clinical trial design and CAR structure have complicated the discovery of the optimal application of this technology. Recent preclinical studies support additional genetic modifications of CAR-modified T cells to achieve optimal clinical efficacy using this novel adoptive cellular therapy." @default.
- W2122027821 created "2016-06-24" @default.
- W2122027821 creator A5055001531 @default.
- W2122027821 creator A5065556543 @default.
- W2122027821 date "2012-01-01" @default.
- W2122027821 modified "2023-10-03" @default.
- W2122027821 title "Novel cellular therapies for leukemia: CAR-modified T cells targeted to the CD19 antigen." @default.
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- W2122027821 doi "https://doi.org/10.1182/asheducation-2012.1.143" @default.
- W2122027821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5536093" @default.
- W2122027821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23233573" @default.
- W2122027821 hasPublicationYear "2012" @default.