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• W2122058374 startingPage "794" @default.
• W2122058374 abstract "Over 200 mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) are known to cause Rett syndrome (RTT), a multiphasic neurodevelopmental disorder that results in motor and cognitive impairments; however, little is known about the neurobiology of RTT. Here, we employ the MeCP2308/y mouse model of RTT to investigate the course of the neuronal defects imparted by MeCP2 mutation. Using the olfactory system as a neurodevelopmental model, we describe an acute but transient defect in olfactory sensory neuron maturation during synaptogenesis and elaboration of the glomerular neuropil. This defect is overcome through compensatory responses that restore homeostasis. However, a chronic problem in glomerular organization emerges, which eventually leads to increased neuronal apoptosis. This multiphasic course comprising acute developmental and chronic defects in synaptogenesis and maintenance may represent the neurobiological correlates of clinical RTT, and suggests that different therapeutic strategies may be appropriate at different clinical stages of this disease." @default.
• W2122058374 created "2016-06-24" @default.
• W2122058374 creator A5022571719 @default.
• W2122058374 creator A5023674564 @default.
• W2122058374 creator A5079861863 @default.
• W2122058374 date "2008-04-01" @default.
• W2122058374 modified "2023-10-15" @default.
• W2122058374 title "MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively" @default.
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• W2122058374 cites W1542222934 @default.
• W2122058374 cites W1559742681 @default.
• W2122058374 cites W1678001779 @default.
• W2122058374 cites W1961943243 @default.
• W2122058374 cites W1965759698 @default.
• W2122058374 cites W1974618036 @default.
• W2122058374 cites W1974814280 @default.
• W2122058374 cites W1977423612 @default.
• W2122058374 cites W1977576332 @default.
• W2122058374 cites W1980069682 @default.
• W2122058374 cites W1981495424 @default.
• W2122058374 cites W1981537755 @default.
• W2122058374 cites W1983022541 @default.
• W2122058374 cites W1983133453 @default.
• W2122058374 cites W1985334727 @default.
• W2122058374 cites W1989096255 @default.
• W2122058374 cites W1990009149 @default.
• W2122058374 cites W1992559178 @default.
• W2122058374 cites W1999775510 @default.
• W2122058374 cites W2000313340 @default.
• W2122058374 cites W2001321749 @default.
• W2122058374 cites W2003573497 @default.
• W2122058374 cites W2003748551 @default.
• W2122058374 cites W2004836530 @default.
• W2122058374 cites W2005044366 @default.
• W2122058374 cites W2010016468 @default.
• W2122058374 cites W2013978625 @default.
• W2122058374 cites W2014364856 @default.
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• W2122058374 cites W2030172814 @default.
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• W2122058374 cites W2035090622 @default.
• W2122058374 cites W2039857019 @default.
• W2122058374 cites W2052422346 @default.
• W2122058374 cites W2057343637 @default.
• W2122058374 cites W2061183136 @default.
• W2122058374 cites W2061311218 @default.
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• W2122058374 cites W2076850467 @default.
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• W2122058374 cites W2127311839 @default.
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• W2122058374 cites W2162529637 @default.
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• W2122058374 doi "https://doi.org/10.1016/j.mcn.2008.01.005" @default.
• W2122058374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18295506" @default.
• W2122058374 hasPublicationYear "2008" @default.
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