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• W2122073994 abstract "ABSTRACT Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type." @default.
• W2122073994 created "2016-06-24" @default.
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• W2122073994 date "2009-03-15" @default.
• W2122073994 modified "2023-10-17" @default.
• W2122073994 title "Cell Type-Specific Induction and Inhibition of Apoptosis by Herpes Simplex Virus Type 2 ICP10" @default.
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• W2122073994 doi "https://doi.org/10.1128/jvi.02088-08" @default.
• W2122073994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2648263" @default.
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